School Of Basic And Applied Sciences

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Subject: search.filters.subject.multicomponent reactions

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    Glycine Catalyzed One-Pot Three-Component Synthesis of Structurally Diverse 2-Amino Substituted Pyran Annulated Heterocycles in Aqueous Ethanol under Refluxed Conditions
    (Bentham Science Publishers, 2022-12-14T00:00:00) Banerjee, Bubun; Kaur, Manmeet; Sharma, Aditi; Singh, Arvind; Priya, Anu; Gupta, Vivek Kumar; Jaitak, Vikas
    Introduction: A facile, convenient and general method has been developed for the one-pot three-component synthesis of structurally diverse 2-amino pyran annulated heterocycles from the reactions of aromatic aldehydes, malononitrile and various C-H activated acids in the presence of a catalytic amount of glycine as an efficient metal-free organocatalyst in aqueous ethanol under refluxed conditions. Methods: Using this developed protocol, we were able to synthesize a series of structurally diverse 2-amino pyran derivatives viz., 2-amino-4,5-dihydropyrano[3,2-c]chromenes, 2-amino-4,5-dihydropyrano [4,3-b]pyrans, 2-amino-5,6,7,8-tetrahydro-4H-chromenes, 2'-amino-2,5'-dioxo-5'H-spiro[indoline-3,4'-pyrano [3,2-c]chromene]-3'-carbonitrile and 2'-amino-1,3,5'-trioxo-1,3-dihydro-5'H-spiro[indene-2,4'-pyrano[3,2-c]chromene]-3'-carbonitrile in excellent yields. Result: Synthesis of biologically promising pyrans and spiropyrans, high atom economy, excellent yields, use of metal-free catalyst, less toxic solvents, no chromatographic column purifications, multiple carbon-carbon and carbon-heteroatom bond formations are some of the major advantages of this newly developed protocol. Conclusion: In conclusion, we have developed a simple, convenient, and efficient method for the synthesis of a series of structurally diverse 2-amino pyran annulated heterocyclic derivatives. � 2022 Bentham Science Publishers.
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    Trisodium citrate dihydrate catalyzed one-pot pseudo four-component synthesis of fully functionalized pyridine derivatives
    (Taylor and Francis Ltd., 2022-07-22T00:00:00) Sharma, Aditi; Singh, Arvind; Priya, Anu; Kaur, Manmeet; Gupta, Vivek Kumar; Jaitak, Vikas; Banerjee, Bubun
    A facile and convenient method has been developed for the one-pot pseudo-four component synthesis of fully functionalized pyridine derivatives from the reactions of aromatic aldehydes, malononitrile and thiols in the presence of a catalytic amount of trisodium citrate dihydrate as an efficient metal-free catalyst in aqueous ethanol under refluxed conditions. All the reactions were completed within just 45 minutes and the desired products afforded in excellent yields (90�95%). Gram scale production of the desired compound was also achieved. Synthesis of biologically promising scaffolds, high atom economy, excellent yields, use of metal-free catalyst, less toxic solvents, no column chromatographic purifications, reusability of the solvent media, multiple carbon-carbon and carbon-heteroatom bond formations are some of the major advantages of this newly developed protocol. � 2022 Taylor & Francis Group, LLC.
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    Recent advances in the C(1)-functionalization of tetrahydroisoquinolines via multicomponent reactions
    (Springer, 2020) Kaur, P; Kumar, R.
    (Figure presented.) 1,2,3,4-Tetrahydroisoquinoline is an important structural motif of various natural products and therapeutic lead compounds. In recent years, considerable research interest has been witnessed toward synthesis of its C(1)-substituted derivatives, since they can act as precursors for various alkaloids displaying multifarious biological activities. This minireview offers short and non-exhaustive epitome of various multicomponent reactions for the C(1)-functionalization of 1,2,3,4-tetrahydroisoquinolines. In particular, reactions involving isomerization of iminium intermediate (exo/endo isomerization) are highlighted for the period of 2013-2019. - 2020, Springer Science+Business Media, LLC, part of Springer Nature.