Antiplatelet drugs: Potential therapeutic options for the management of neurodegenerative diseases

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dc.contributor.authorBeura, Samir K.
dc.contributor.authorDhapola, Rishika
dc.contributor.authorPanigrahi, Abhishek R.
dc.contributor.authorYadav, Pooja
dc.contributor.authorKumar, Reetesh
dc.contributor.authorReddy, Dibbanti H.
dc.contributor.authorSingh, Sunil K.
dc.date.accessioned2024-01-21T10:55:12Z
dc.date.accessioned2024-08-14T07:44:25Z
dc.date.available2024-01-21T10:55:12Z
dc.date.available2024-08-14T07:44:25Z
dc.date.issued2023-05-03T00:00:00
dc.description.abstractThe blood platelet plays an important role but often remains under-recognized in several vascular complications and associated diseases. Surprisingly, platelet hyperactivity and hyperaggregability have often been considered the critical risk factors for developing vascular dysfunctions in several neurodegenerative diseases (NDDs) like Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis. In addition, platelet structural and functional impairments promote prothrombotic and proinflammatory environment that can aggravate the progression of several NDDs. These findings provide the rationale for using antiplatelet agents not only to prevent morbidity but also to reduce mortality caused by NDDs. Therefore, we thoroughly review the evidence supporting the potential pleiotropic effects of several novel classes of synthetic antiplatelet drugs, that is, cyclooxygenase inhibitors, adenosine diphosphate receptor antagonists, protease-activated receptor blockers, and glycoprotein IIb/IIIa receptor inhibitors in NDDs. Apart from this, the review also emphasizes the recent developments of selected natural antiplatelet phytochemicals belonging to key classes of plant-based bioactive compounds, including polyphenols, alkaloids, terpenoids, and flavonoids as potential therapeutic candidates in NDDs. We believe that the broad analysis of contemporary strategies and specific approaches for plausible therapeutic treatment for NDDs presented in this review could be helpful for further successful research in this area. � 2023 Wiley Periodicals LLC.en_US
dc.identifier.doi10.1002/med.21965
dc.identifier.issn1986325
dc.identifier.urihttp://10.2.3.109/handle/32116/4371
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/med.21965
dc.language.isoen_USen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectantiplatelet drugsen_US
dc.subjectHuntington's diseaseen_US
dc.subjectmultiple sclerosisen_US
dc.subjectnatural phytochemicalsen_US
dc.subjectParkinson's diseaseen_US
dc.titleAntiplatelet drugs: Potential therapeutic options for the management of neurodegenerative diseasesen_US
dc.title.journalMedicinal Research Reviewsen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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