Targeting Breast Cancer-Derived Stem Cells by Dietary Phytochemicals: A Strategy for Cancer Prevention and Treatment

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dc.contributor.authorPrajapati, Kumari Sunita
dc.contributor.authorGupta, Sanjay
dc.contributor.authorKumar, Shashank
dc.date.accessioned2024-01-16T14:23:14Z
dc.date.accessioned2024-08-13T10:34:10Z
dc.date.available2024-01-16T14:23:14Z
dc.date.available2024-08-13T10:34:10Z
dc.date.issued2022-06-10T00:00:00
dc.description.abstractBreast cancer is heterogeneous disease with variable prognosis and therapeutic response. Approximately, 70% of diagnosed breast cancer represents the luminal A subtype. This subpopulation has a fair prognosis with a lower rate of relapse than the other clinical subtypes. Acquisition of stemness in luminal A subtype modifies the phenotype plasticity to accomplish increased aggressiveness and therapeutic resistance. Therefore, targeting luminal A-derived breast cancer stem cells (BCSCs) could be a promising strategy for its prevention and treatment. Extensive studies reveal that dietary phytochemicals have the potential to target BCSCs by modulating the molecular and signal transduction pathways. Dietary phytochemicals alone or in combination with standard therapeutic modalities exert higher efficacy in targeting BCSCs through changes in stemness, self-renewal properties and hypoxia-related factors. These combinations offer achieving higher radio-and chemo-sensitization through alteration in the key signaling pathways such as AMPK, STAT3, NF-kB, Hedgehog, PI3K/Akt/mTOR, Notch, GSK3?, and Wnt related to cancer stemness and drug resistance. In this review, we highlight the concept of targeting luminal A-derived BCSCs with dietary phytochemicals by summarizing the pathways and underlying mechanism(s) involved during therapeutic resistance. � 2022 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.identifier.doi10.3390/cancers14122864
dc.identifier.issn20726694
dc.identifier.urihttps://doi.org/10.3390/cancers14122864
dc.identifier.urihttp://10.2.3.109/handle/32116/2881
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.subjectbreast cancer stem cellsen_US
dc.subjectcancer preventionen_US
dc.subjectdietary phytochemicalen_US
dc.subjectluminal A subtypeen_US
dc.subjectsignaling pathwayen_US
dc.subjecttherapeutic resistanceen_US
dc.titleTargeting Breast Cancer-Derived Stem Cells by Dietary Phytochemicals: A Strategy for Cancer Prevention and Treatmenten_US
dc.title.journalCancersen_US
dc.typeReviewen_US
dc.type.accesstypeOpen Accessen_US

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