Let-7a induces metabolic reprogramming in breast cancer cells via targeting mitochondrial encoded ND4

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dc.contributor.authorSharma, Praveen
dc.contributor.authorSharma, Vibhuti
dc.contributor.authorAhluwalia, Tarunveer Singh
dc.contributor.authorDogra, Nilambra
dc.contributor.authorKumar, Santosh
dc.contributor.authorSingh, Sandeep
dc.date.accessioned2024-01-21T10:54:03Z
dc.date.accessioned2024-08-14T07:40:49Z
dc.date.available2024-01-21T10:54:03Z
dc.date.available2024-08-14T07:40:49Z
dc.date.issued2021-11-27T00:00:00
dc.description.abstractBackground and objectives: MicroRNA (miRNA) that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNA (mitomiR). Albeit mitomiRs have been shown to modulate gene expression, their functional impact within mitochondria is unknown. The main objective of this study is to investigate whether the mitochondrial genome is regulated by miR present inside the mitochondria. Methods and results: Here, we report mitomiR let-7a regulates mitochondrial transcription in breast cancer cells and reprogram the metabolism accordingly. These effects were mediated through the interaction of let-7a with mtDNA, as studied by RNA pull-down assays, altering the activity of Complex I in a cell line-specific manner. Our study, for the first time, identifies the role of mitomiR (let-7a) in regulating the mitochondrial genome by transcriptional repression and its contribution to regulating mitochondrial metabolism of breast cancer cells. Conclusion: These findings uncover a novel mechanism by which mitomiR regulates mitochondrial transcription. � 2021, The Author(s).en_US
dc.identifier.doi10.1186/s12935-021-02339-3
dc.identifier.issn14752867
dc.identifier.urihttp://10.2.3.109/handle/32116/4196
dc.identifier.urlhttps://cancerci.biomedcentral.com/articles/10.1186/s12935-021-02339-3
dc.language.isoen_USen_US
dc.publisherBioMed Central Ltden_US
dc.subjectCanceren_US
dc.subjectGlycolysisen_US
dc.subjectMetabolic reprogrammingen_US
dc.subjectMito-miRsen_US
dc.subjectMitochondriaen_US
dc.titleLet-7a induces metabolic reprogramming in breast cancer cells via targeting mitochondrial encoded ND4en_US
dc.title.journalCancer Cell Internationalen_US
dc.typeArticleen_US
dc.type.accesstypeOpen Accessen_US

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