Chemical composition and antiproliferative, antioxidant, and proapoptotic effects of fruiting body extracts of the lingzhi or reishi medicinal mushroom, ganoderma lucidum (Agaricomycetes), from India

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dc.contributor.authorGill, B.S.
dc.contributor.authorSharma, P.
dc.contributor.authorNavgeet, Kumar, S.
dc.date.accessioned2018-07-14T01:18:37Z
dc.date.accessioned2024-08-13T11:04:19Z
dc.date.available2018-07-14T01:18:37Z
dc.date.available2024-08-13T11:04:19Z
dc.date.issued2016
dc.description.abstractGanoderma lucidum is a renowned medicinal mushroom exploited as a panacea because of the broad spectrum of its bioactivities, which give it invaluable nutritional and clinical implications. This research was implemented with an incentive to explore and quantify various macromolecules encompassed in the oriental fungus; these vary in concentration with respect to the development/growth phase, host plants, and geographic location of collection. Chemical profiling of G. lucidum confirmed the presence of myco-constituents, their amounts varying in response to extreme climatic conditions. G. lucidum extract exhibited elevated levels of all myco-constituents but flavonoids, which were more pronounced when in a parasitic relationship with their host plants. Proapoptotic efficiency portrayed by the extracts against a prostate cancer cell line (PC-3) was also found to be similar. The samples collected from the Bathinda region, with Azadirachta and Acacia trees as the host plants, showed several-fold augmentation in levels of G. lucidum gredients compared with other variants. Elevated levels of myco-constituents highlight their significance in inhibiting prostate cancer cell proliferation, reducing reactive oxygen species, suppressing invasive potential, and inducing apoptosis. It was thus concluded that G. lucidum grown on Azadirachta plants was more efficient in exhibiting potent biological activities than G. lucidum grown on other host plants. ? 2016 Begell House, Inc.en_US
dc.identifier.citationGill, B. S., Sharma, P., Navgeet, & Kumar, S. (2016). Chemical composition and antiproliferative, antioxidant, and proapoptotic effects of fruiting body extracts of the lingzhi or reishi medicinal mushroom, ganoderma lucidum (Agaricomycetes), from India. International Journal of Medicinal Mushrooms, 18(7), 599-607. doi: 10.1615/IntJMedMushrooms.v18.i7.50en_US
dc.identifier.doi10.1615/IntJMedMushrooms.v18.i7.50
dc.identifier.issn15219437
dc.identifier.urihttp://10.2.3.109/handle/32116/1264
dc.identifier.urlhttp://www.dl.begellhouse.com/journals/708ae68d64b17c52,65a55c177b27d486,0441f5b24eb9846c.html
dc.language.isoenen_US
dc.publisherBegell House Inc.en_US
dc.subjectGanoderma Lucidum Extracten_US
dc.subjectProtein Baxen_US
dc.subjectReactive Oxygen Metaboliteen_US
dc.subjectAntineoplastic Activityen_US
dc.subjectAntioxidant Activityen_US
dc.subjectAntiproliferative Activityen_US
dc.subjectApoptosis Biochemical Analysisen_US
dc.subjectCell Proliferation Assayen_US
dc.subjectCell Viabilityen_US
dc.subjectChemical Compositionen_US
dc.subjectControlled Studyen_US
dc.subjectCytotoxicityen_US
dc.subjectDpph Radical Scavenging Assayen_US
dc.subjectFruiting Bodyen_US
dc.subjectGanoderma Lucidumen_US
dc.subjectGene Expressionen_US
dc.subjectHumanen_US
dc.subjectHuman Cellen_US
dc.subjectMtt Assayen_US
dc.subjectNonhumanen_US
dc.subjectProtein Expressionen_US
dc.subjectReverse Transcription Polymerase Chain Reactionen_US
dc.titleChemical composition and antiproliferative, antioxidant, and proapoptotic effects of fruiting body extracts of the lingzhi or reishi medicinal mushroom, ganoderma lucidum (Agaricomycetes), from Indiaen_US
dc.title.journalInternational Journal of Medicinal Mushrooms
dc.typeArticleen_US

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