KI-assisted Sulfur Activation/Insertion/Denitration Strategy towards Dual C?S Bond Formation for One-pot Synthesis of ?-Carboline-tethered 2-Acylbenzothiophenes
| dc.contributor.author | Singh, Manpreet | |
| dc.contributor.author | Jamra., Rahul | |
| dc.contributor.author | Paul, Avijit K. | |
| dc.contributor.author | Malakar, Chandi C. | |
| dc.contributor.author | Singh, Virender | |
| dc.date.accessioned | 2024-01-21T10:32:58Z | |
| dc.date.accessioned | 2024-08-13T11:16:40Z | |
| dc.date.available | 2024-01-21T10:32:58Z | |
| dc.date.available | 2024-08-13T11:16:40Z | |
| dc.date.issued | 2021-12-13T00:00:00 | |
| dc.description.abstract | A simple and efficient KI promoted sulfur activation-insertion/de-nitration strategy has been developed for the synthesis of ?-carboline C1 tethered 2-acylbenzothiophenes via one-pot assembly of 1-acetyl ?-carbolines (an alkaloid based scaffold), 2-nirobenzaldehydes and elemental sulfur. This expeditious reaction proceeds through the formation of ?-carboline linked nitro-chalcones followed by embodiment of elemental sulfur to generate the multifunctional ?-carboline linked benzothiophene derivatives. The highlighted features of this efficient methodology are transition metal-free conditions, use of inexpensive and non-toxic catalyst, easy procedure, short reaction time, and broad substrate scope with good yields. The scope of this protocol has been extended for the synthesis of a range of novel compounds with significant diversity. � 2021 Wiley-VCH GmbH | en_US |
| dc.identifier.doi | 10.1002/ajoc.202100653 | |
| dc.identifier.issn | 21935807 | |
| dc.identifier.uri | https://kr.cup.edu.in/handle/32116/3226 | |
| dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/ajoc.202100653 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | John Wiley and Sons Inc | en_US |
| dc.subject | 1-Acetyl ?-carboline | en_US |
| dc.subject | 2-Acylbenzothiophene | en_US |
| dc.subject | De-nitration | en_US |
| dc.subject | Sulfur insertion | en_US |
| dc.subject | Transition metal-free | en_US |
| dc.title | KI-assisted Sulfur Activation/Insertion/Denitration Strategy towards Dual C?S Bond Formation for One-pot Synthesis of ?-Carboline-tethered 2-Acylbenzothiophenes | en_US |
| dc.title.journal | Asian Journal of Organic Chemistry | en_US |
| dc.type | Article | en_US |
| dc.type.accesstype | Closed Access | en_US |