Antimicrobial and anti-viral effects of selenium nanoparticles and selenoprotein based strategies: COVID-19 and beyond

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dc.contributor.authorKhurana, Amit
dc.contributor.authorAllawadhi, Prince
dc.contributor.authorSingh, Vishakha
dc.contributor.authorKhurana, Isha
dc.contributor.authorYadav, Poonam
dc.contributor.authorSathua, Kshirod Bihari
dc.contributor.authorAllwadhi, Sachin
dc.contributor.authorBanothu, Anil Kumar
dc.contributor.authorNavik, Umashanker
dc.contributor.authorBharani, Kala Kumar
dc.date.accessioned2024-01-21T10:55:14Z
dc.date.accessioned2024-08-14T07:44:26Z
dc.date.available2024-01-21T10:55:14Z
dc.date.available2024-08-14T07:44:26Z
dc.date.issued2023-06-08T00:00:00
dc.description.abstractDeficiency of selenium (Se) has been described in a significant number of COVID-19 patients having a higher incidence of mortality, which makes it a pertinent issue to be addressed clinically for effective management of the COVID-19 pandemic. Se nanoparticles (SeNPs) provide a unique option for managing the havoc caused by the COVID-19 pandemic. SeNPs possess promising anti-inflammatory and anti-fibrotic effects by virtue of their nuclear factor kappa-light-chain-stimulator of activated B cells (NF?B), mitogen-activated protein kinase (MAPKs), and transforming growth factor-beta (TGF-?) modulatory activity. In addition, SeNPs possess remarkable immunomodulatory effects, making them a suitable option for supplementation with a much lower risk of toxicity compared to their elemental counterpart. Further, SeNPs have been shown to curtail viral and microbial infections, thus, making it a novel means to halt viral growth. In addition, it can be administered in the form of aerosol spray, direct injection, or infused thin-film transdermal patches to reduce the spread of this highly contagious viral infection. Moreover, a considerable decrease in the expression of selenoprotein along with enhanced expression of IL-6 in COVID-19 suggests a potential association among selenoprotein expression and COVID-19. In this review, we highlight the unique antimicrobial and antiviral properties of SeNPs and the immunomodulatory potential of selenoproteins. We provide the rationale behind their potentially interesting properties and further exploration in the context of microbial and viral infections. Further, the importance of selenoproteins and their role in maintaining a successful immune response along with their association to Se status is summarized. � 2023 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.jddst.2023.104663
dc.identifier.issn17732247
dc.identifier.urihttp://10.2.3.109/handle/32116/4377
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S1773224723005154
dc.language.isoen_USen_US
dc.publisherEditions de Santeen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectAntimicrobialen_US
dc.subjectAntiviralen_US
dc.subjectCOVID-19en_US
dc.subjectSelenium nanoparticlesen_US
dc.subjectSelenoproteinsen_US
dc.titleAntimicrobial and anti-viral effects of selenium nanoparticles and selenoprotein based strategies: COVID-19 and beyonden_US
dc.title.journalJournal of Drug Delivery Science and Technologyen_US
dc.typeReviewen_US
dc.type.accesstypeOpen Accessen_US

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