Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity
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2013
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Abstract
Design, synthesis and anticancer activity of a series of imine-pyrazolopyrimidinones is reported for the first time. Compounds 9d, 9n and 9o in the series show encouraging in vitro anticancer activity with low micromolar IC50 values against prostate (PC3) and breast (MCF7) cancer cell lines. Some notions about structure-activity relationships and plausible mechanism of biological activity are presented. ? 2013 Elsevier Ltd. All rights reserved.
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5 (2 chlorobenzylideneamino) 1 benzyl 6,7 dihydro 6 (2 chlorophenyl) 1h pyrazolo[3,4 d]pyrimidin 4 (5h)one, 5 (3 methoxy 4 hydroxybenzylideneamino) 1 benzyl 1h pyrazolo[3,4 d]pyrimidin 4 (5h)one, 5 (4 methoxybenzylideneamino) 1 benzyl 6,7 dihydro 6 (4 methoxyphenyl) 1h pyrazolo[3,4 d]pyrimidin 4 (5h)one, Antineoplastic agent, Etoposide, Imine pyrazolopyrimidinone, Pyrimidinone derivative, Unclassified drug, Antineoplastic activity, Antiproliferative activity, Article, Cell cycle progression, Con
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Baviskar, A. T., Banerjee, U. C., Gupta, M., Singh, R., Kumar, S., Gupta, M. K., . . . Kumar, R. (2013). Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity. Bioorganic and Medicinal Chemistry, 21(18), 5782-5793. doi: 10.1016/j.bmc.2013.07.016