Epigenetic Instability Caused by Oxidative Stress Triggers Tumorigenesis

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dc.contributor.authorPreet Kaur, Raman
dc.contributor.authorKaur, Prabhsimran
dc.contributor.authorMunshi, Anjana
dc.date.accessioned2024-01-21T10:54:04Z
dc.date.accessioned2024-08-14T07:40:50Z
dc.date.available2024-01-21T10:54:04Z
dc.date.available2024-08-14T07:40:50Z
dc.date.issued2022-01-31T00:00:00
dc.description.abstractCancer is a multifactorial disease that is caused by various modifiable as well as non-modifiable factors. Among non-modifiable factors, genetic and epigenetic factors have been reported to play a critical role in the progression of cancer. Epigenetics refers to the change in gene expression without any change in the genome. The major epigenome targets include modification of histones by either methylation or acetylation and methylation of DNA at CpG islands. Change in acetylation and methylation pattern leads to not only inhibition of tumor suppressor genes but also the activation of oncogenes. Oxidative stress is a significant phenomenon observed in human body as a result of various intracellular as well as extracellular factors. This stress interferes with the function of histone methyltransferases and histone deacetylases, resulting in modifications of the epigenome. Further, these oxidative stress-induced epigenetic modifications may occur at various regions, including the promoters of tumor suppressor genes. These result in silencing of genes, leading to increased cell proliferation. In addition, reactive oxygen species have also been found to be involved in regulating the various steps of tumor development, including transformation, survival, proliferation, invasion, metastasis, and angiogenesis. Therefore, oxidative stress can be used as a target for developing cancer-related treatment modalities that reduce oxidative stress levels and thereby help in the resumption of the normal activity of epigenetic enzymes preserving epigenetic integrity. � Springer Nature Singapore Pte Ltd. 2022.en_US
dc.identifier.doi10.1007/978-981-15-9411-3_184
dc.identifier.isbn9789811594113
dc.identifier.isbn9789811594106
dc.identifier.urihttp://10.2.3.109/handle/32116/4205
dc.identifier.urlhttps://link.springer.com/10.1007/978-981-15-9411-3_184
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.subjectEpigenetic instabilityen_US
dc.subjectGlobal hypomethylationen_US
dc.subjectOxidative stressen_US
dc.subjectRegional hypermethylationen_US
dc.subjectTumorigenesisen_US
dc.titleEpigenetic Instability Caused by Oxidative Stress Triggers Tumorigenesisen_US
dc.title.journalHandbook of Oxidative Stress in Cancer: Mechanistic Aspectsen_US
dc.typeBook chapteren_US
dc.type.accesstypeClosed Accessen_US

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Human Genetics And Molecular Medicine - Research Publications