Eradicating Cancer Stem Cells: Concepts, Issues, and Challenges

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dc.contributor.authorKaur, Gurpreet
dc.contributor.authorSharma, Praveen
dc.contributor.authorDogra, Nilambra
dc.contributor.authorSingh, Sandeep
dc.date.accessioned2018-07-14T01:18:44Z
dc.date.accessioned2024-08-14T06:40:10Z
dc.date.available2018-07-14T01:18:44Z
dc.date.available2024-08-14T06:40:10Z
dc.date.issued2018
dc.description.abstractThe cells of malignant cancers result in the evolution of cells with stem-like characteristics, commonly known as cancer stem cells (CSCs). Progress of anticancer therapies is severely hampered because of disease relapse mostly in a more aggressive form due to CSCs. These CSCs are more or less like embryonic or tissue stem cells, known for their capacity of self-renewal, exactly recapitulate of the original tumor. Deregulation of key stem cell pathways like Wnt, Hedgehog (Hh), and Notch is attributed towards the rise of CSCs. Recent breakthroughs offer better insights into CSC signaling. Scientists have developed several combinatorial therapies like targeting one/multiple of these CSC pathways. The article summarized various markers used to identify CSCs and discuss major signaling pathways in them. The futuristic probabilities to use CSC therapeutics in clinical development have been discussed. Our views have been highlighted on the future directions for targeting advances in the clinical development. ? 2018, Springer Science+Business Media, LLC, part of Springer Nature.en_US
dc.identifier.citationKaur, G., Sharma, P., Dogra, N., & Singh, S. (2018). Eradicating Cancer Stem Cells: Concepts, Issues, and Challenges. Current Treatment Options in Oncology, 19(4). doi: 10.1007/s11864-018-0533-1en_US
dc.identifier.doi10.1007/s11864-018-0533-1
dc.identifier.issn15272729
dc.identifier.urihttp://10.2.3.109/handle/32116/1318
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs11864-018-0533-1
dc.language.isoen_USen_US
dc.publisherSpringer New York LLCen_US
dc.titleEradicating Cancer Stem Cells: Concepts, Issues, and Challengesen_US
dc.title.journalCurrent Treatment Options in Oncologyen_US
dc.typeReviewen_US

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