Caesium carbonate promoted regioselective O-functionalization of 4,6-diphenylpyrimidin-2(1H)-ones under mild conditions and mechanistic insight
dc.contributor.author | Kumar, Vijay | |
dc.contributor.author | Singh, Praval Pratap | |
dc.contributor.author | Dwivedi, Ashish Ranjan | |
dc.contributor.author | Kumar, Naveen | |
dc.contributor.author | Rakesh kumar, None | |
dc.contributor.author | Chandra Sahoo, Subash | |
dc.contributor.author | Chakraborty, Sudip | |
dc.contributor.author | Kumar, Vinod | |
dc.date.accessioned | 2024-01-21T10:34:44Z | |
dc.date.accessioned | 2024-08-13T11:13:25Z | |
dc.date.available | 2024-01-21T10:34:44Z | |
dc.date.available | 2024-08-13T11:13:25Z | |
dc.date.issued | 2023-06-05T00:00:00 | |
dc.description.abstract | A facile one-step catalyst free methodology has been developed for the regioselective functionalization of 4,6-diphenylpyrimidin-2(1H)-ones under mild conditions. Selectivity towards the O-regioisomer was achieved by using Cs2CO3 in DMF without use of any coupling reagents. A total of 14 regioselective O-alkylated 4,6-diphenylpyrimidines were synthesized in 81-91% yield. In the DFT studies it was observed that the transition state for the formation of the O-regioisomer is more favourable with Cs2CO3 as compared to K2CO3. Furthermore, this methodology was extended to increase the O/N ratio for the alkylation of 2-phenylquinazolin-4(3H)-one derivatives. � 2023 The Royal Society of Chemistry. | en_US |
dc.identifier.doi | 10.1039/d3ra00773a | |
dc.identifier.issn | 20462069 | |
dc.identifier.uri | http://10.2.3.109/handle/32116/3316 | |
dc.identifier.url | http://xlink.rsc.org/?DOI=D3RA00773A | |
dc.language.iso | en_US | en_US |
dc.publisher | Royal Society of Chemistry | en_US |
dc.subject | Potash | en_US |
dc.subject | Regioselectivity | en_US |
dc.subject | Catalyst-free | en_US |
dc.subject | Condition | en_US |
dc.subject | Coupling reagents | en_US |
dc.subject | DFT study | en_US |
dc.subject | Functionalizations | en_US |
dc.subject | Mechanistics | en_US |
dc.subject | Regio-selective | en_US |
dc.subject | Regioisomers | en_US |
dc.subject | Regioselective functionalization | en_US |
dc.subject | Synthesised | en_US |
dc.subject | Cesium compounds | en_US |
dc.title | Caesium carbonate promoted regioselective O-functionalization of 4,6-diphenylpyrimidin-2(1H)-ones under mild conditions and mechanistic insight | en_US |
dc.title.journal | RSC Advances | en_US |
dc.type | Article | en_US |
dc.type.accesstype | Open Access | en_US |