Caesium carbonate promoted regioselective O-functionalization of 4,6-diphenylpyrimidin-2(1H)-ones under mild conditions and mechanistic insight

dc.contributor.authorKumar, Vijay
dc.contributor.authorSingh, Praval Pratap
dc.contributor.authorDwivedi, Ashish Ranjan
dc.contributor.authorKumar, Naveen
dc.contributor.authorRakesh kumar, None
dc.contributor.authorChandra Sahoo, Subash
dc.contributor.authorChakraborty, Sudip
dc.contributor.authorKumar, Vinod
dc.date.accessioned2024-01-21T10:34:44Z
dc.date.accessioned2024-08-13T11:13:25Z
dc.date.available2024-01-21T10:34:44Z
dc.date.available2024-08-13T11:13:25Z
dc.date.issued2023-06-05T00:00:00
dc.description.abstractA facile one-step catalyst free methodology has been developed for the regioselective functionalization of 4,6-diphenylpyrimidin-2(1H)-ones under mild conditions. Selectivity towards the O-regioisomer was achieved by using Cs2CO3 in DMF without use of any coupling reagents. A total of 14 regioselective O-alkylated 4,6-diphenylpyrimidines were synthesized in 81-91% yield. In the DFT studies it was observed that the transition state for the formation of the O-regioisomer is more favourable with Cs2CO3 as compared to K2CO3. Furthermore, this methodology was extended to increase the O/N ratio for the alkylation of 2-phenylquinazolin-4(3H)-one derivatives. � 2023 The Royal Society of Chemistry.en_US
dc.identifier.doi10.1039/d3ra00773a
dc.identifier.issn20462069
dc.identifier.urihttp://10.2.3.109/handle/32116/3316
dc.identifier.urlhttp://xlink.rsc.org/?DOI=D3RA00773A
dc.language.isoen_USen_US
dc.publisherRoyal Society of Chemistryen_US
dc.subjectPotashen_US
dc.subjectRegioselectivityen_US
dc.subjectCatalyst-freeen_US
dc.subjectConditionen_US
dc.subjectCoupling reagentsen_US
dc.subjectDFT studyen_US
dc.subjectFunctionalizationsen_US
dc.subjectMechanisticsen_US
dc.subjectRegio-selectiveen_US
dc.subjectRegioisomersen_US
dc.subjectRegioselective functionalizationen_US
dc.subjectSynthesiseden_US
dc.subjectCesium compoundsen_US
dc.titleCaesium carbonate promoted regioselective O-functionalization of 4,6-diphenylpyrimidin-2(1H)-ones under mild conditions and mechanistic insighten_US
dc.title.journalRSC Advancesen_US
dc.typeArticleen_US
dc.type.accesstypeOpen Accessen_US

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