Biomedical applications of polysaccharide nanoparticles for chronic inflammatory disorders: Focus on rheumatoid arthritis, diabetes and organ fibrosis

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dc.contributor.authorAllawadhi, Prince
dc.contributor.authorSingh, Vishakha
dc.contributor.authorGovindaraj, Kannan
dc.contributor.authorKhurana, Isha
dc.contributor.authorSarode, Lopmudra P.
dc.contributor.authorNavik, Umashanker
dc.contributor.authorBanothu, Anil Kumar
dc.contributor.authorWeiskirchen, Ralf
dc.contributor.authorBharani, Kala Kumar
dc.contributor.authorKhurana, Amit
dc.date.accessioned2024-01-21T10:54:59Z
dc.date.accessioned2024-08-14T07:44:17Z
dc.date.available2024-01-21T10:54:59Z
dc.date.available2024-08-14T07:44:17Z
dc.date.issued2021-11-22T00:00:00
dc.description.abstractPolysaccharides are biopolymers distinguished by their complex secondary structures executing various roles in microorganisms, plants, and animals. They are made up of long monomers of similar type or as a combination of other monomeric chains. Polysaccharides are considered superior as compared to other polymers due to their diversity in charge and size, biodegradability, abundance, bio-compatibility, and less toxicity. These natural polymers are widely used in designing of nanoparticles (NPs) which possess wide applications in therapeutics, diagnostics, delivery and protection of bioactive compounds or drugs. The side chain reactive groups of polysaccharides are advantageous for functionalization with nanoparticle-based conjugates or therapeutic agents such as small molecules, proteins, peptides and nucleic acids. Polysaccharide NPs show excellent pharmacokinetic and drug delivery properties, facilitate improved oral absorption, control the release of drugs, increases in vivo retention capability, targeted delivery, and exert synergistic effects. This review updates the usage of polysaccharides based NPs particularly cellulose, chitosan, hyaluronic acid, alginate, dextran, starch, cyclodextrins, pullulan, and their combinations with promising applications in diabetes, organ fibrosis and arthritis. � 2021 Elsevier Ltden_US
dc.identifier.doi10.1016/j.carbpol.2021.118923
dc.identifier.issn1448617
dc.identifier.urihttp://10.2.3.109/handle/32116/4301
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0144861721013102
dc.language.isoen_USen_US
dc.publisherElsevier Ltden_US
dc.subjectArthritisen_US
dc.subjectDrug deliveryen_US
dc.subjectInflammationen_US
dc.subjectNanoparticlesen_US
dc.subjectPolysaccharidesen_US
dc.titleBiomedical applications of polysaccharide nanoparticles for chronic inflammatory disorders: Focus on rheumatoid arthritis, diabetes and organ fibrosisen_US
dc.title.journalCarbohydrate Polymersen_US
dc.typeReviewen_US
dc.type.accesstypeOpen Accessen_US

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