Prevalence of Amoebiasis and Associated Complications in India: A Systematic Review

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dc.contributor.authorGupta, Palak
dc.contributor.authorSingh, Kiran Kumari
dc.contributor.authorBalodhi, Ashutosh
dc.contributor.authorJain, Khushi
dc.contributor.authorDeeba, Farah
dc.contributor.authorSalam, Nasir
dc.date.accessioned2024-01-21T10:26:42Z
dc.date.accessioned2024-08-13T11:19:31Z
dc.date.available2024-01-21T10:26:42Z
dc.date.available2024-08-13T11:19:31Z
dc.date.issued2022-04-11T00:00:00
dc.description.abstractPurpose: Intestinal protozoan parasites are responsible for diarrheal diseases causing significant morbidity and mortality. Entamoeba histolytica is the principle protozoan parasite associated with diarrheal infections. The infection is often associated with inaccessibility to clean drinking water and poor sanitary conditions in low- and middle-income countries including India. A comprehensive systematic review was performed to evaluate a reliable nationwide estimate for prevalence and geographic distribution of amoebiasis in India and the complications associated with it. Methods: We used the PRISMA guidelines to perform a systematic review and meta-analysis of articles published between the year 2001�2020. Two English language databases PubMed and Web of Science were searched to achieve relevant studies. Results: Initial searches resulted in 467 studies out of which 64 eligible articles involving data from 289,659 human subjects from 12 states and 4 union territories were included in the final analysis. Prevalence of amoebiasis ranged from 3-23% in asymptomatic population, 0.64�11% in symptomatic patients and 1�17.5% in HIV-infected patients. Highest prevalence was seen in Tamil Nadu, Andaman Nicobar Island and North East India. Extra intestinal invasion of Entamoeba histolytica leading to complications such as amoebic liver abscess, amoebic colitis, colonic perforation and ameboma were also reported. Such complications have the potential to increase healthcare burden and may prove to be fatal. Conclusion: Amoebiasis remains a significant public health issue in India responsible for diarrheal diseases causing significant morbidity and mortality. Entamoeba histolytica is the principle protozoan parasite associated with amoebiasis. Public health efforts should be directed towards its control and better diagnostic methods should be employed for distinguishing between pathogenic and non-pathogenic species of Entamoeba. � 2022, The Author(s) under exclusive licence to Witold Stefa?ski Institute of Parasitology, Polish Academy of Sciences.en_US
dc.identifier.doi10.1007/s11686-022-00547-z
dc.identifier.issn12302821
dc.identifier.urihttp://10.2.3.109/handle/32116/3106
dc.identifier.urlhttps://link.springer.com/10.1007/s11686-022-00547-z
dc.language.isoen_USen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.subjectAmoebiasisen_US
dc.subjectAmoebic liver abscessen_US
dc.subjectEntamoebaen_US
dc.subjectIndiaen_US
dc.subjectPrevalenceen_US
dc.titlePrevalence of Amoebiasis and Associated Complications in India: A Systematic Reviewen_US
dc.title.journalActa Parasitologicaen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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