Molecular docking simulation study of phytoestrogens asparagus racemosus in breast cancer progression

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dc.contributor.authorSingla, Ramit
dc.contributor.authorJaitak, Vikas
dc.date.accessioned2017-08-02T09:25:31Z
dc.date.accessioned2024-08-13T12:05:28Z
dc.date.available2017-08-02T09:25:31Z
dc.date.available2024-08-13T12:05:28Z
dc.date.issued2015
dc.description.abstractPhytoestrogens are the xenoestrogens which are derived from the plant. This is the first report providing the deeper inside into the mechanism involved in restricting breast cancer progression with the help of docking simulation by phytoestrogen. Docking experiment bring to light that phytoestrogens prevents the binding of oestradiol with its receptor, thereby down regulating the signalling pathway and also acts as inhibitor of enzymes involved in the biosynthesis of endogenous oestradiol. In the present study, thirty phytoestrogen reported from A. racemosus were selected as ligand along with reference compounds using Maestro 9.3. Rutin, shatavarin I, 3, 6, 4' – trimethoxy-7-O-β-D- glucopyranosyl [1→4]-O-α-D-xylopyranoside glucopyranpsyl, 8-methoxy-5,6,4-trihydroxyisoflavone-7-O-β-D-glucopyranoside,shatavarin X, racemoside A, immunoside showed better interactions with their targets indicated from their respective dock score.en_US
dc.identifier.citationSingla, R and Jaitak, V. (2015) MOLECULAR DOCKING SIMULATION STUDY OF PHYTOESTROGENS ASPARAGUS RACEMOSUS IN BREAST CANCER PROGRESSION.International Journal Of Pharmaceutical Sciences And Research 6(1), 172-182. (I.F.: 1.79)en_US
dc.identifier.issnPrint- 2320-5148
dc.identifier.issnOnline- 0975-8232
dc.identifier.urihttp://10.2.3.109/handle/32116/267
dc.language.isoenen_US
dc.publisherInternational Journal Of Pharmaceutical Sciences And Research (IJPSR)en_US
dc.subjectOestrogen receptorsen_US
dc.subjectglucose-6-phosphate dehydrogenaseen_US
dc.subjectHSP90en_US
dc.subjectsteroid sulphataseen_US
dc.subjecttubulinen_US
dc.subject17β-hydroxysteroid dehydrogenaseen_US
dc.subjectin-silico; phytoestrogensen_US
dc.titleMolecular docking simulation study of phytoestrogens asparagus racemosus in breast cancer progressionen_US
dc.typeArticleen_US

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