Overview of genetic and epigenetic regulation of human papillomavirus and apoptosis in cervical cancer

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dc.contributor.authorYadav, Chetna
dc.contributor.authorYadav, Ritu
dc.contributor.authorChabbra, Ravindresh
dc.contributor.authorNanda, Smiti
dc.contributor.authorRanga, Shalu
dc.contributor.authorKadian, Lokesh
dc.contributor.authorAhuja, Parul
dc.date.accessioned2024-01-16T14:23:21Z
dc.date.accessioned2024-08-13T10:34:15Z
dc.date.available2024-01-16T14:23:21Z
dc.date.available2024-08-13T10:34:15Z
dc.date.issued2023-01-18T00:00:00
dc.description.abstractCervical cancer is the fourth most common cancer affecting women worldwide after breast, colorectal and lung cancers. Owing to a lack of awareness and resources, low- and middle-income countries bear most of the burden of cervical cancer. In developed countries, the incidence rate has been halved over the past three decades due to robust screening and implementation of vaccine programs. HPV is not the sole cause of cervical cancer but acts as a principal factor in the pathogenesis of cervical cancer. By integrating into the host genome, its oncogenic proteins (E6 and E7) alter and interfere with the standard signal transduction machinery of the host. Apoptosis is a key pathway affected by aberrant genetic mutations, polymorphisms and epigenetic mechanisms during cervical carcinogenesis. Along with DNA methylation and histone modifications, non-coding RNAs have also been implicated as epigenetic modulators in various malignancies and are being explored for reversing disease severity. This review emphasizes various genetic and epigenetic approaches regulating apoptotic pathways and HPV E6 and E7 genes that can be targeted to overcome the challenges in cervical cancer treatment. In addition, it also discusses the apoptosis targeting novel drug molecules in cervical cancer which are currently undergoing clinical and pre-clinical trials. � 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.en_US
dc.identifier.doi10.1007/s10495-023-01812-w
dc.identifier.issn13608185
dc.identifier.urihttps://doi.org/10.1007/s10495-023-01812-w
dc.identifier.urihttp://10.2.3.109/handle/32116/2913
dc.language.isoen_USen_US
dc.publisherSpringeren_US
dc.subjectApoptosisen_US
dc.subjectCervical canceren_US
dc.subjectHuman papillomavirusen_US
dc.subjectTherapeutic approachesen_US
dc.titleOverview of genetic and epigenetic regulation of human papillomavirus and apoptosis in cervical canceren_US
dc.title.journalApoptosisen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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