Colistin Resistance and Management of Drug Resistant Infections

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dc.contributor.authorSharma, Juhi
dc.contributor.authorSharma, Divakar
dc.contributor.authorSingh, Amit
dc.contributor.authorSunita, Kumari
dc.date.accessioned2024-01-21T10:37:05Z
dc.date.accessioned2024-08-13T11:19:28Z
dc.date.available2024-01-21T10:37:05Z
dc.date.available2024-08-13T11:19:28Z
dc.date.issued2022-12-10T00:00:00
dc.description.abstractColistin resistance is a globalized sensible issue because it has been considered a drug of the last-line resort to treat drug-resistant bacterial infections. The product of the mobilized colistin resistance (mcr) gene and its variants are the significant causes of colistin resistance, which is emerging due to the frequent colistin use in veterinary, and these genes circulate among the bacterial community. Apart from mcr genes, some other intrinsic genes and proteins are also involved in colistin resistance. Researchers focus on the most advanced genomics (whole genome sequencing), proteomics, and bioinformatics approaches to explore the question of colistin resistance. To combat colistin resistance, researchers developed various strategies such as the development of newer drugs, the repurposing of existing drugs, combinatorial treatment by colistin with other drugs, a nano-based approach, photodynamic therapy, a CRISPRi-based strategy, and a phage-based strategy. In this timeline review, we have discussed the development of colistin resistance and its management in developing countries. � 2022 Juhi Sharma et al.en_US
dc.identifier.doi10.1155/2022/4315030
dc.identifier.issn17129532
dc.identifier.urihttp://10.2.3.109/handle/32116/3479
dc.identifier.urlhttps://www.hindawi.com/journals/cjidmm/2022/4315030/
dc.language.isoen_USen_US
dc.publisherHindawi Limiteden_US
dc.subjectavibactam plus ceftazidimeen_US
dc.subjectcarbapenemaseen_US
dc.subjectceftolozane plus tazobactamen_US
dc.subjectcolistimethateen_US
dc.subjectcolistinen_US
dc.subjectlipopolysaccharideen_US
dc.subjectmeropenem plus vaborbactamen_US
dc.subjectpolymyxinen_US
dc.subjectAcinetobacter baumanniien_US
dc.subjectantibiotic resistanceen_US
dc.subjectantibiotic sensitivityen_US
dc.subjectbacterial infectionen_US
dc.subjectbioinformaticsen_US
dc.subjectcolistin resistanceen_US
dc.subjectDrug Resistant Infectionen_US
dc.subjectEnterobacteralesen_US
dc.subjectEnterobacteriaceaeen_US
dc.subjectmeningitisen_US
dc.subjectnephrotoxicityen_US
dc.subjectnonhumanen_US
dc.subjectosteomyelitisen_US
dc.subjectPaenibacillus polymyxaen_US
dc.subjectphotodynamic therapyen_US
dc.subjectPseudomonasen_US
dc.subjectPseudomonas aeruginosaen_US
dc.subjectpyodermaen_US
dc.subjectReviewen_US
dc.subjecturinary tract infectionen_US
dc.subjectwhole genome sequencingen_US
dc.titleColistin Resistance and Management of Drug Resistant Infectionsen_US
dc.title.journalCanadian Journal of Infectious Diseases and Medical Microbiologyen_US
dc.typeReviewen_US
dc.type.accesstypeOpen Accessen_US

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