Multitargeted molecular docking study of natural-derived alkaloids on breast cancer pathway components

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dc.contributor.authorSingla, Ramit
dc.contributor.authorJaitak, Vikas
dc.date.accessioned2018-07-14T01:18:57Z
dc.date.accessioned2024-08-13T12:06:16Z
dc.date.available2018-07-14T01:18:57Z
dc.date.available2024-08-13T12:06:16Z
dc.date.issued2017
dc.description.abstractBackground: Targeting of multiple sites is a pharmacologically, pharmacokinetic and dynamically more acceptable approach for complex diseases such as BC. It is recommended that the women who are at high risk of developing BC might be given foods enhanced by indole alkaloids from vegetables like cabbage and broccoli. Administration of indole-3-carbinol is associated with decreased incidence of hormone-responsive BC (HRBC) which is implicated due to the induction of cytochrome P450 and glutathione-S-transferase which metabolizes chemical mutagens and by altering estrogen metabolism. Objective: To determine the molecular mechanism behind the anticancer activity of natural indole alkaloids present in various food and nutraceuticals products by utilizing Induced-fit docking (IFD) approach. Methods: Indole alkaloids were obtained from the database maintained by ChEBI (The database and ontology of Chemical Entities of Biological Interest) with ChEBI id 38958. The 3-dimentional and X-ray structure coordinates of Estrogen receptor- ? (ER-?), Estrogen receptor- ? (ER-?), and aromatase were obtained from protein data bank with PDB id codes 3ERT, 3OLS, and 3S7S (www.rcsb.org). The Induced fit molecular docking and ADME properties were calculated using Maestro 9.6. Results: IFD analysis showed that bromocriptine exhibits maximum binding affinity towards ER-? and fellutanine B towards ER-? and aromatase. Conclusion: Present research provided in-depth analysis of molecular mechanism and helped in the future design of new pharmacophores based on natural indole alkaloids targeting BC. ? 2017 Bentham Science Publishers.en_US
dc.identifier.citationSingla, R., & Jaitak, V. (2017). Multitargeted molecular docking study of natural-derived alkaloids on breast cancer pathway components. Current Computer-Aided Drug Design, 13(4), 294-302. doi: 10.2174/1573409913666170406144642en_US
dc.identifier.doi10.2174/1573409913666170406144642
dc.identifier.issn15734099
dc.identifier.urihttp://10.2.3.109/handle/32116/1400
dc.identifier.urlhttp://www.eurekaselect.com/151385/article
dc.language.isoen_USen_US
dc.publisherBentham Science Publishers B.V.en_US
dc.subject1 methoxycanthinoneen_US
dc.subjectAgroclavineen_US
dc.subjectAlcuroniumen_US
dc.subjectAlkaloid derivativeen_US
dc.subjectAmbiguine h isonitrileen_US
dc.subjectAromataseen_US
dc.subjectBromocriptineen_US
dc.subjectCorynanen_US
dc.subjectCorynantheineen_US
dc.subjectCryptolepineen_US
dc.subjectDrymaritinen_US
dc.subjectEllipticineen_US
dc.subjectErgoline derivativeen_US
dc.subjectEstradiolen_US
dc.subjectFellutanine aen_US
dc.subjectFellutanine ben_US
dc.subjectnutraceuticalen_US
dc.subjectvincaneen_US
dc.titleMultitargeted molecular docking study of natural-derived alkaloids on breast cancer pathway componentsen_US
dc.title.journalCurrent Computer-Aided Drug Design
dc.typeArticleen_US

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