Natural Compounds Are Smart Players in Context to Anticancer Potential of Receptor Tyrosine Kinases: An In Silico and In Vitro Advancement

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dc.contributor.authorSingh, Pushpendra
dc.contributor.authorKumar, Shashank
dc.contributor.authorBast, Felix
dc.date.accessioned2018-02-23T07:26:16Z
dc.date.accessioned2024-08-13T10:34:10Z
dc.date.available2018-02-23T07:26:16Z
dc.date.available2024-08-13T10:34:10Z
dc.date.issued2017
dc.description.abstractCancer is the ruling cause of mortality worldwide. Chemotherapeutic toxicity and drug resistance have provided impulsion for the formulation of new anticancer agents. Receptor tyrosine kinases (RTKs) are the most activated cell surface receptors for copious polypeptide growth factors, cytokines, and hormones that play a considerable role in cancer initiation, promotion, and progression. Natural products are a prime source of new anticancer drugs and their leads. The objective of computer-aided drug design (CADD) is to enhance the set of compounds with prudent active drug-like properties and eliminate inactive, toxic, poor absorption, distribution, metabolism, and excretion toxicity (ADME/T) compounds. In the present chapter, in silico advancement of anticancer natural compounds and molecular mechanisms of action of flavonoids, viz., genistein, myricetin, quercetin, luteolin, morin, kaempferol, catechin, and epigallocatechin gallate (EGCG), on RTK and PI3K signaling pathway attributing to their potential anticancer activity have been discussed.en_US
dc.identifier.citationPushpendra Singh, Shashank Kumar, and Felix Bast. Natural Compounds Are Smart Players in Context to Anticancer Potential of Receptor Tyrosine Kinases: An In Silico and In Vitro Advancement. Translational Bioinformatics and Its Application, Translational Medicine Research, DOI 10.1007/978-94-024-1045-7_8en_US
dc.identifier.isbnPrint- 978-94-024-1043-3
dc.identifier.issnOnline- 978-94-024-1045-7
dc.identifier.urihttp://10.2.3.109/handle/32116/613
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectReceptor tyrosine kinasesen_US
dc.subjectCanceren_US
dc.subjectNatural compoundsen_US
dc.subjectComputer-aided drug designen_US
dc.titleNatural Compounds Are Smart Players in Context to Anticancer Potential of Receptor Tyrosine Kinases: An In Silico and In Vitro Advancementen_US
dc.typeBook chapteren_US

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