Role of prostate cancer stem-like cells in the development of antiandrogen resistance

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dc.contributor.authorKushwaha, Prem Prakash
dc.contributor.authorVerma, Shiv
dc.contributor.authorKumar, Shashank
dc.contributor.authorGupta, Sanjay
dc.date.accessioned2024-01-16T14:23:14Z
dc.date.accessioned2024-08-13T10:34:10Z
dc.date.available2024-01-16T14:23:14Z
dc.date.available2024-08-13T10:34:10Z
dc.date.issued2022-06-09T00:00:00
dc.description.abstractAndrogen deprivation therapy (ADT) is the standard of care treatment for advance stage prostate cancer. Treatment with ADT develops resistance in multiple ways leading to the development of castration-resistant prostate cancer (CRPC). Present research establishes that prostate cancer stem-like cells (CSCs) play a central role in the development of treatment resistance followed by disease progression. Prostate CSCs are capable of self-renewal, differentiation, and regenerating tumor heterogeneity. The stemness properties in prostate CSCs arise due to various factors such as androgen receptor mutation and variants, epigenetic and genetic modifications leading to alteration in the tumor microenvironment, changes in ATP-binding cassette (ABC) transporters, and adaptations in molecular signaling pathways. ADT reprograms prostate tumor cellular machinery leading to the expression of various stem cell markers such as Aldehyde Dehydrogenase 1 Family Member A1 (ALDH1A1), Prominin 1 (PROM1/CD133), Indian blood group (CD44), SRY-Box Transcription Factor 2 (Sox2), POU Class 5 Homeobox 1(POU5F1/Oct4), Nanog and ABC transporters. These markers indicate enhanced self-renewal and stemness stimulating CRPC evolution, metastatic colonization, and resistance to antiandrogens. In this review, we discuss the role of ADT in prostate CSCs differentiation and acquisition of CRPC, their isolation, identification and characterization, as well as the factors and pathways contributing to CSCs expansion and therapeutic opportunities. � The Author(s) 2022.en_US
dc.identifier.doi10.20517/cdr.2022.07
dc.identifier.issn2578532X
dc.identifier.urihttps://doi.org/10.20517/cdr.2022.07
dc.identifier.urihttp://10.2.3.109/handle/32116/2880
dc.language.isoen_USen_US
dc.publisherOAE Publishing Inc.en_US
dc.subjectandrogen deprivation therapyen_US
dc.subjectcancer stem cellsen_US
dc.subjectcastration resistance prostate canceren_US
dc.subjectProstate canceren_US
dc.subjectsecond-generation antiandrogensen_US
dc.titleRole of prostate cancer stem-like cells in the development of antiandrogen resistanceen_US
dc.title.journalCancer Drug Resistanceen_US
dc.typeReviewen_US
dc.type.accesstypeOpen Accessen_US

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