Stem cells in the treatment of Alzheimer's disease � Promises and pitfalls

dc.contributor.authorBhatti, Jasvinder Singh
dc.contributor.authorKhullar, Naina
dc.contributor.authorMishra, Jayapriya
dc.contributor.authorKaur, Satinder
dc.contributor.authorSehrawat, Abhishek
dc.contributor.authorSharma, Eva
dc.contributor.authorBhatti, Gurjit Kaur
dc.contributor.authorSelman, Ashley
dc.contributor.authorReddy, P. Hemachandra
dc.date.accessioned2024-01-21T10:54:13Z
dc.date.accessioned2024-08-14T07:40:57Z
dc.date.available2024-01-21T10:54:13Z
dc.date.available2024-08-14T07:40:57Z
dc.date.issued2023-04-06T00:00:00
dc.description.abstractAlzheimer's disease (AD) is the most widespread form of neurodegenerative disorder that causes memory loss and multiple cognitive issues. The underlying mechanisms of AD include the build-up of amyloid-? and phosphorylated tau, synaptic damage, elevated levels of microglia and astrocytes, abnormal microRNAs, mitochondrial dysfunction, hormonal imbalance, and age-related neuronal loss. However, the etiology of AD is complex and involves a multitude of environmental and genetic factors. Currently, available AD medications only alleviate symptoms and do not provide a permanent cure. Therefore, there is a need for therapies that can prevent or reverse cognitive decline, brain tissue loss, and neural instability. Stem cell therapy is a promising treatment for AD because stem cells possess the unique ability to differentiate into any type of cell and maintain their self-renewal. This article provides an overview of the pathophysiology of AD and existing pharmacological treatments. This review article focuses on the role of various types of stem cells in neuroregeneration, the potential challenges, and the future of stem cell-based therapies for AD, including nano delivery and gaps in stem cell technology. � 2023 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.bbadis.2023.166712
dc.identifier.issn9254439
dc.identifier.urihttps://kr.cup.edu.in/handle/32116/4248
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0925443923000789
dc.language.isoen_USen_US
dc.publisherElsevier B.V.en_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectAmyloid-? plaquesen_US
dc.subjectBlood-brain barrieren_US
dc.subjectNanoparticlesen_US
dc.subjectNeurofibrillary tanglesen_US
dc.subjectStem cell therapyen_US
dc.titleStem cells in the treatment of Alzheimer's disease � Promises and pitfallsen_US
dc.title.journalBiochimica et Biophysica Acta - Molecular Basis of Diseaseen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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