In vitro and In silico study of Essential oil Components from Eucalyptus tereticornis as Antibacterial agents

Simple item page
dc.contributor.authorSharma, Anupama
dc.contributor.supervisorJaitak,Vikas
dc.date.accessioned2018-08-31T04:13:48Z
dc.date.accessioned2024-08-13T11:24:39Z
dc.date.available2018-08-31T04:13:48Z
dc.date.available2024-08-13T11:24:39Z
dc.date.issued2018
dc.description.abstractMany essential oils are known for their antimicrobial activity and the main target is bacterial cell membrane which is important for bacterial viability and hence the study was done to find the target and effective binding of the components of the Eucalyptus tereticornis essential oil and comparison with the standard drug used for in vitro and in silico studies, A/S combination. In vitro and In silico studies has shown the potential of Eucalyptus tereticornis essential oil in modulating antibacterial resistance and its potential as an antibacterial agent at a conc. of 10µl that was comparable with the standard and also at 50 µl, the zone of inhibition was found to be equivalent to that of standard combinational drug of A/S (10:10) mcg. The In silico studies further confirms its potential to combat antibacterial resistance as the docking results has shown the effective binding of the components of essential oil than the standard in the order ?-Terpinyl acetate (-2.754)> 8-epi-gama-eudermol> beta-eudesmol> L-alpha-Terpineol against PBP3 in comparison with the standard (-0.766). Docking simulation also suggests the effective binding of essential oil components with the beta lactamases as (-2.348) for Salbactam in comparison with (-3.671) Cis-p-mentha-1(7),8-dien-2-ol and also ADME/T studies has shown their ability to partition the bacterial cell membrane with logPo/w for the components for Aromadendrene (5.176), beta-myrcene (4.592). Along with 100% oral 6 absorption and the absorption through gut blood barrier QPPCaco found to be more than 500 for every component of the essential oil, and brain blood barrier that was found to be in range of 0.095 for alpha-terpinylacetate and 1.047 for Aromadendrene.en_US
dc.identifier.accessionnoT00633
dc.identifier.citationSharma, Anupama (2018) In vitro and In silico study of Essential oil Components from Eucalyptus tereticornis as Antibacterial agentsen_US
dc.identifier.urihttp://10.2.3.109/handle/32116/1934
dc.language.isoen_USen_US
dc.publisherCentral University of Punjaben_US
dc.subjectEucalyptus tereticornisen_US
dc.subjectGC-MS analysisen_US
dc.subjectAntibacterial Resistanceen_US
dc.subjectantibacterial activityen_US
dc.subjectA/Sen_US
dc.subjectEssential Oilen_US
dc.subjectIn-vitroen_US
dc.subjectIn-silicoen_US
dc.titleIn vitro and In silico study of Essential oil Components from Eucalyptus tereticornis as Antibacterial agentsen_US
dc.typeMaster Dissertationen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
T00633.pdf
Size:
2.57 MB
Format:
Adobe Portable Document Format
Download

Collections

Pharmaceutical Sciences and Natural Products - Master Dissertation
Master's Dissertations