Implications of cancer stem cells in diabetes and pancreatic cancer

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dc.contributor.authorMukherjee, Anirban Goutam
dc.contributor.authorWanjari, Uddesh Ramesh
dc.contributor.authorGopalakrishnan, Abilash Valsala
dc.contributor.authorBradu, Pragya
dc.contributor.authorSukumar, Aarthi
dc.contributor.authorPatil, Megha
dc.contributor.authorRenu, Kaviyarasi
dc.contributor.authorDey, Abhijit
dc.contributor.authorVellingiri, Balachandar
dc.contributor.authorGeorge, Alex
dc.contributor.authorGanesan, Raja
dc.date.accessioned2024-01-21T10:44:42Z
dc.date.accessioned2024-08-13T13:21:45Z
dc.date.available2024-01-21T10:44:42Z
dc.date.available2024-08-13T13:21:45Z
dc.date.issued2022-11-19T00:00:00
dc.description.abstractThis review provides a detailed study of pancreatic cancer (PC) and the implication of different types of cancers concerning diabetes. The combination of anti-diabetic drugs with other anti-cancer drugs and phytochemicals can help prevent and treat this disease. PC cancer stem cells (CSCs) and how they migrate and develop into malignant tumors are discussed. A detailed explanation of the different mechanisms of diabetes development, which can enhance the pancreatic CSCs' proliferation by increasing the IGF factor levels, epigenetic modifications, DNA damage, and the influence of lifestyle factors like obesity, and inflammation, has been discussed. It also explains how cancer due to diabetes is associated with high mortality rates. One of the well-known diabetic drugs, metformin, can be combined with other anti-cancer drugs and prevent the development of PC and has been taken as one of the prime focus in this review. Overall, this paper provides insight into the relationship between diabetes and PC and the methods that can be employed to diagnose this disease at an earlier stage successfully. � 2022 Elsevier Inc.en_US
dc.identifier.doi10.1016/j.lfs.2022.121211
dc.identifier.issn243205
dc.identifier.urihttp://10.2.3.109/handle/32116/3835
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0024320522009110
dc.language.isoen_USen_US
dc.publisherElsevier Inc.en_US
dc.subjectBiomarkersen_US
dc.subjectCSCsen_US
dc.subjectDiabetesen_US
dc.subjectPathophysiologyen_US
dc.subjectPCen_US
dc.subjectTreatmentsen_US
dc.titleImplications of cancer stem cells in diabetes and pancreatic canceren_US
dc.title.journalLife Sciencesen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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