Association of UGT1A6 2 (Ser7Ala) polymorphism with therapeutic response to aspirin in ischemic stroke patients

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dc.contributor.authorKumar, Dharmendra
dc.contributor.supervisorMunshi,Anjana
dc.date.accessioned2018-08-31T04:13:45Z
dc.date.accessioned2024-08-14T07:04:07Z
dc.date.available2018-08-31T04:13:45Z
dc.date.available2024-08-14T07:04:07Z
dc.date.issued2018
dc.description.abstractIschemic stroke occurs due to the formation of thrombus or embolism within the arteries due to platelet aggregation. Aspirin therapy is used for the prevention of secondary stroke. The variant of UGT1A6 (Ser7Ala) gene has been found to be associated with ischemic stroke as well as aspirin resistance. We aim to study the demographic profile of ischemic stroke patients from Malwa region of Punjab and to evaluate the frequency of UGT1A6*2 Ser7Ala polymorphism and correlate it with aspirin resistance and ADRs (if any). We collected 30 samples from confirmed ischemic stroke patients from Guru Gobind Singh Medical College and Hospital in Malwa region of Punjab. DNA was isolated from blood and PCR- RFLP technique was used to evaluate the UGT1A6 gene variant in the patients. mRS value was used to classify patients as responders or nonresponders. 24 patients had TT genotype and 6 patients were found to bear TG genotype. 90% of patients were aspirin responders and 10% were aspirin nonresponders. Since the sample size was too low to identify significant associations, a large number of samples should be screened before coming to a conclusion. However, this preliminary study indicates that UGT1A6*2 (Ser7Ala) variant of UGT1A6 gene might be a risk factor for aspirin resistance in the studied group.en_US
dc.identifier.accessionnoT00674
dc.identifier.citationkumar, Dharmendra (2018) Association of UGT1A6 2 (Ser7Ala) polymorphism with therapeutic response to aspirin in ischemic stroke patientsen_US
dc.identifier.urihttp://10.2.3.109/handle/32116/1895
dc.language.isoen_USen_US
dc.publisherCentral University of Punjaben_US
dc.subjectIschemic Strokeen_US
dc.subjectAspirinen_US
dc.subjectAspirin Resistanceen_US
dc.subjectUgt1A6 Geneen_US
dc.subjectSer7Ala Polymorphismen_US
dc.titleAssociation of UGT1A6 2 (Ser7Ala) polymorphism with therapeutic response to aspirin in ischemic stroke patientsen_US
dc.typeMaster Dissertationen_US

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Human Genetics And Molecular Medicine - Master Dissertation
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