Ferulic acid ameliorates neurodegeneration via the Nrf2/ARE signalling pathway: A Review

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dc.contributor.authorSingh, Surbhi
dc.contributor.authorArthur, Richmond
dc.contributor.authorUpadhayay, Shubham
dc.contributor.authorKumar, Puneet
dc.date.accessioned2024-01-21T10:55:07Z
dc.date.accessioned2024-08-14T07:44:22Z
dc.date.available2024-01-21T10:55:07Z
dc.date.available2024-08-14T07:44:22Z
dc.date.issued2022-10-30T00:00:00
dc.description.abstractBackground: Ferulic acid is a polyphenolic phytoconstituent synthesized from the metabolism of amino acids phenylalanine and tyrosine found in fruits and vegetables. Neurodegenerative disorders have been a thorn in the flesh of neuroscientists owing in part to the increase in the aged population. Several drugs used in the management of these disorders are either ineffective or come with unbearable side effects. We present a review of ferulic acid focusing on leveraging its antioxidant property in an attempt to explain its role in neurodegenerative disorders. Basic procedure: data were obtained by perusing scientific databases including Web of Science and PubMed. It was realised that 18,000 articles were associated with ferulic acid from 1960-to 2022. We narrowed it down using the keywords neuroprotection, and antioxidant of which we had 239 articles. Main findings: results indicated that ferulic acid has wide neuropharmacological applications due to its antioxidant, anti-inflammatory, neuroprotective and antiapoptotic effects among others. The neuroprotective effect of ferulic acid has been studied in many diseases like Alzheimer's, Epilepsy, and Parkinson's disease. Principal conclusion: the neuroprotective potential of FA may be due to its ability to absorb active forms of oxygen and nitrogen and use redox-bearing compounds to regulate genetic expression including, encoding for antioxidant enzymes, the anti-apoptotic protein family Bcl-2, and pro-survival neurotrophic factors like BDNF. Its higher bioavailability and lipophilic nature make it a better drug candidate than other polyphenols for neurological disorders. � 2022 The Author(s)en_US
dc.identifier.doi10.1016/j.prmcm.2022.100190
dc.identifier.issn26671425
dc.identifier.urihttp://10.2.3.109/handle/32116/4344
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S2667142522001506
dc.language.isoen_USen_US
dc.publisherElsevier B.V.en_US
dc.subjectAntioxidanten_US
dc.subjectApoptosisen_US
dc.subjectExcitotoxicityen_US
dc.subjectFerulic aciden_US
dc.subjectNeuroinflammationen_US
dc.subjectOxidative stressen_US
dc.titleFerulic acid ameliorates neurodegeneration via the Nrf2/ARE signalling pathway: A Reviewen_US
dc.title.journalPharmacological Research - Modern Chinese Medicineen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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