Synthesis and xanthine oxidase inhibitory activity of 5,6 dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives

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dc.contributor.authorKumar, Deependra
dc.contributor.authorKaur, Gagandeep
dc.contributor.authorNegi, Arvind
dc.contributor.authorKumar, Sanjeev
dc.contributor.authorSingh, Sandeep
dc.contributor.authorKumar, Raj
dc.date.accessioned2017-08-08T05:15:18Z
dc.date.accessioned2024-08-13T12:05:58Z
dc.date.available2017-08-08T05:15:18Z
dc.date.available2024-08-13T12:05:58Z
dc.date.issued2014
dc.description.abstractSome 5,6-dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives were rationally designed, synthesized and evaluated for in vitro xanthine oxidase inhibitory activity for the first time. Some notions about structure activity relationships are presented. The compounds 6g, 6h and 6e were found to be significantly active against XO. The compound 6g emerged as the most potent XO inhibitor as compared to allopurinol and free radical scavenger. The molecular docking of 6g into the XO active site highlighted its mode of binding and important interactions such as hydrogen bonding, π–π stacking with amino acid residues like Ser876, Thr1010, Phen914, Phe1009 and Phe649 and its close proximity to dioxothiomolybdenum (MOS).en_US
dc.identifier.citationKumar D, Kaur G, Negi Akumar S, Singh S, Kumar R*(2014) Synthesis and xanthine oxidase inhibitory activity of 5,6 dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives. Bioorganic Chemistry, 57, 57-64 (I.F.: 20141)en_US
dc.identifier.doi10.1016/j.bioorg.2014.08.007
dc.identifier.issn0045-2068
dc.identifier.urihttp://10.2.3.109/handle/32116/291
dc.identifier.urlhttps://www.sciencedirect.com/science/article/abs/pii/S0045206814000741
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectXanthine oxidaseen_US
dc.subject5,6-Dihydropyrazolo/pyrazolo[1,5-c]quinazolineen_US
dc.subjectSynthesis Molecular modelingen_US
dc.subjectAntioxidanten_US
dc.titleSynthesis and xanthine oxidase inhibitory activity of 5,6 dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivativesen_US
dc.title.journalBioorganic Chemistry
dc.typeArticleen_US

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