Berberine Ameliorate Haloperidol and 3-Nitropropionic Acid-Induced Neurotoxicity in Rats

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dc.contributor.authorKadir, Abdul
dc.contributor.authorSingh, Jasdeep
dc.contributor.authorRahi, Vikrant
dc.contributor.authorKumar, Puneet
dc.date.accessioned2024-01-21T10:55:04Z
dc.date.accessioned2024-08-14T07:44:20Z
dc.date.available2024-01-21T10:55:04Z
dc.date.available2024-08-14T07:44:20Z
dc.date.issued2022-07-25T00:00:00
dc.description.abstractBerberine due to its antioxidant properties, has been used around the globe significantly to treat several brain disorders. Also, oxidative stress is a pathological hallmark in neurodegenerative diseases like Huntington�s disease (HD) and Tardive dyskinesia (TD). Berberine an alkaloid from plants has been reported to have neuroprotective potential in several animal models of neurodegenerative diseases. Hence, this study aims to evaluate the neuroprotective effect of berberine in the animal model of 3-nitropropionic acid (3-NP) induced HD and haloperidol induced tardive dyskinesia with special emphasis on its antioxidant property. The study protocol was divided into 2 phases, first phase involved the administration of 3-NP and berberine at the dose of (25, 50, and 100�mg/kg) intraperitoneally (i.p) and orally (p.o.) respectively for 21�days, and the following parameters (rotarod, narrow beam walk and photoactometer) as a measure of motor activity and striatal and cortical levels of (LPO, GSH, SOD, catalase, and nitrate) evaluated as a measure of oxidative stress were assessed for HD. Similarly in the second phase, TD was induced by using haloperidol, for 21�days and berberine at the dose of (25, 50, and 100�mg/kg) was administered, and both physical and biochemical parameters were assessed as mentioned for the HD study. The resultant�data indicated that berberine attenuate 3-NP and haloperidol-induced behavioral changes and improved the antioxidant capcity in rodents. Hence berberine might be a novel therapeutic candidate to manage TD & HD. � 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.en_US
dc.identifier.doi10.1007/s11064-022-03677-y
dc.identifier.issn3643190
dc.identifier.urihttp://10.2.3.109/handle/32116/4327
dc.identifier.urlhttps://link.springer.com/10.1007/s11064-022-03677-y
dc.language.isoen_USen_US
dc.publisherSpringeren_US
dc.subject3-Nitropropionic aciden_US
dc.subjectAntioxidanten_US
dc.subjectAntipsychoticsen_US
dc.subjectBerberineen_US
dc.subjectFree radicalsen_US
dc.subjectHuntington's diseaseen_US
dc.subjectOxidative stressen_US
dc.subjectTardive dyskinesiaen_US
dc.titleBerberine Ameliorate Haloperidol and 3-Nitropropionic Acid-Induced Neurotoxicity in Ratsen_US
dc.title.journalNeurochemical Researchen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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