Interaction between topoisomerases and histone deacetylases: Role in cancer progression and therapeutic interventions
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Date
2017
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Nova Science Publishers, Inc.
Abstract
DNA topoisomerases are termed as the magicians of the DNA world, as they are involved in overcoming all the topological DNA problems. Histone Deacetylases are the collection of enzymes that assist in the regulation of DNA control. The overexpression of topoisomerases and histone deacetylases are found in various diseases including cancer. Till date, many therapies have been discovered to target topoisomerases and histone deacetylases individually. However, most of these treatments are associated with the toxicities and drug resistance. The drug resistance apart from known mechanism(s) could occur due to crosstalk(s) of topoisomerases with various proteins associated directly or indirectly with the cancer prognosis. Histone deacetylases that render topoisomerase inhibitors resistant also insensitize them toward binding to the receptor. The chapter overlays the discussion on the underlying mechanism(s) involved in topoisomerase and histone deacetylases interactions. The chapter also congregates the information suggested for the essential pharmacophore development for such hybrid drug discovery. The attempt has also been made to give a preliminary virtual background on the fundamental interaction of these two proteins along with the primary amino acids involved in such interaction. ? 2017 Nova Science Publishers, Inc.
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Joshi, G., Thakur, A., Kaur, G., Kalra, S., Singh, S., & Kumar, R. (2017). Interaction between topoisomerases and histone deacetylases: Role in cancer progression and therapeutic interventions Topoisomerase Inhibitors: Classification, Mechanisms of Action and Adverse Effects (pp. 229-258).