Investigating regulatory signatures of human autophagy related gene 5 (ATG5) through functional in silico analysis

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dc.contributor.authorVij, Avni
dc.contributor.authorRandhawa, Rohit
dc.contributor.authorParkash, Jyoti
dc.contributor.authorChangotra, Harish
dc.contributor.authorVij, A.
dc.contributor.authorRandhawa, R.
dc.contributor.authorParkash, J.
dc.contributor.authorChangotra, H.
dc.date.accessioned2018-01-05T11:09:23Z
dc.date.accessioned2024-08-13T13:21:59Z
dc.date.available2018-01-05T11:09:23Z
dc.date.available2024-08-13T13:21:59Z
dc.date.issued2016
dc.description.abstractAutophagy is an essential, homeostatic process which removes damaged cellular proteins and organelles for cellular renewal. ATG5, a part of E3 ubiquitin ligase-like complex (Atg12-Atg5/Atg16L1), is a key regulator involved in autophagosome formation - a crucial phase of autophagy. In this study, we used different in silico methods for comprehensive analysis of ATG5 to investigate its less explored regulatory activity. We have predicted various physico-chemical parameters and two possible transmembrane models that helped in exposing its functional regions. Twenty four PTM sites and 44 TFBS were identified which could be targeted to modulate the autophagy pathway. Furthermore, LD analysis identified 3 blocks of genotyped SNPs and 2 deleterious nsSNPs that may have damaging impact on protein function and thus could be employed for carrying genome-wide association studies. In conclusion, the information obtained in this study could be helpful for better understanding of regulatory roles of ATG5 and provides a base for its implication in population-based studies. ? 2016 Elsevier B.V.en_US
dc.identifier.citationVij, A., Randhawa, R., Parkash, J., & Changotra, H. (2016). Investigating regulatory signatures of human autophagy related gene 5 (ATG5) through functional in silico analysis. Meta Gene, 9, 237-248. doi: 10.1016/j.mgene.2016.07.012en_US
dc.identifier.doi10.1016/j.mgene.2016.07.012
dc.identifier.issn22145400
dc.identifier.urihttp://10.2.3.109/handle/32116/499
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S2214540016300354?via%3Dihub
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.subjectAlgorithmen_US
dc.subjectAmino Acid Sequence Autophagyen_US
dc.subjectBiodiversityen_US
dc.subjectComputer Modelen_US
dc.subjectCorrelation Coefficienten_US
dc.subjectGeneen_US
dc.subjectGene Linkage Disequilibriumen_US
dc.subjectGenotyping Techniqueen_US
dc.subjectHumanen_US
dc.subjectHuman Autophagy Related Gene 5en_US
dc.subjectMass Spectrometryen_US
dc.subjectNerve Degenerationen_US
dc.subjectPhylogenetic Treeen_US
dc.subjectProbabilityen_US
dc.subjectProtein Interactionen_US
dc.subjectProtein Processingen_US
dc.subjectProtein Structureen_US
dc.subjectSingle Nucleotide Polymorphismen_US
dc.titleInvestigating regulatory signatures of human autophagy related gene 5 (ATG5) through functional in silico analysisen_US
dc.title.journalMeta Gene
dc.typeArticleen_US

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