Protective role of natural products and bioactive compounds in multiple sclerosis

Abstract

Multiple sclerosis (MS), a chronic multifactorial disease characterized by progressive demyelination and neurodegeneration, is rising rapidly in young adults. The pathology of the disease is not yet understood completely. However, neuroinflammation, oxidative stress, and hyperactive autoimmune response appear to play a prominent role in the pathogenesis of the disease. Several genetic, nongenetic, and environmental factors are also found associated with this autoimmune disorder. Although, it is still a matter of debate whether diet and lifestyle have an influence during the course of MS. Recent studies have highlighted several beneficial characteristics of natural bioactive compounds such as anti-inflammatory, antioxidative, immunomodulatory, and other neuroprotective effects, indicating their therapeutic potential to reduce the risk or ameliorate the progression of MS. Basically, these bioactive compounds are the chemicals found in minute amounts naturally in plants with peculiar health benefits. In this chapter, we have briefly described various natural bioactive compounds with neuroprotective effects against MS, including the polyphenols, vitamins supplementation, and natural products such as ginger, ashwagandha, and it seems that these compounds play a notable role in the treatment of MS. Further research is required to extend our understanding in developing more effective therapeutic strategies against the disease with lesser side effects. � 2023 Elsevier Inc. All rights reserved.