Oxidative stress in the development of genetic generalised epilepsy: An observational study in southern Indian population

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dc.contributor.authorPrasad, D.K.V.
dc.contributor.authorSatyanarayana, U.
dc.contributor.authorShaheen, U.
dc.contributor.authorSurya Prabha, T.
dc.contributor.authorMunshi, A.
dc.date.accessioned2018-07-14T01:19:01Z
dc.date.accessioned2024-08-14T07:41:20Z
dc.date.available2018-07-14T01:19:01Z
dc.date.available2024-08-14T07:41:20Z
dc.date.issued2017
dc.description.abstractIntroduction: Oxidative stress resulting from excessive generation of Reactive Oxygen Species (ROS) plays a significant role in neurodegeneration associated with seizures/epilepsy. Aim: To evaluate oxidative stress markers and antioxidant enzymes in Genetic Generalised Epilepsy (GGE) and to know the extent of oxidative stress induced by Anti-Epileptic Drugs (AEDs) with the time duration of treatment. Materials and Methods: In this case-control study, 310 GGE patients (male:female=203:107), who were on AED treatment (n=235) and 75 untreated patients (male:female=49:26) along with 310 age and sex matched healthy controls were recruited. Oxidative stress markers such as Nitric Oxide (NO), Malondialdehyde (MDA) and antioxidant enzyme activities namely Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx) and Catalase (CAT) were measured spectrophotometrically. Results: Significantly higher levels of serum NO, MDA and low levels of plasma Total Antioxidant Capacity (TAC) were found in patients as compared to controls (p<0.001) whereas erythrocyte SOD, CAT and GPx activities were found to be significantly low in patients when compared to the control group (p<0.001). Statistically significant higher levels of NO, MDA and lower levels of SOD, CAT and TAC were observed in patients subgroup, who were on AEDs for more than >5 years compared to other groups (? 1 year and 1-? 5 years) (p=0.02, p=0.01, p=0.001, p=0.01 and p=0.05 respectively). Further, significant increase in the levels of NO, MDA and decreased activities of SOD, CAT were found in treated patients compared to untreated patients (p<0.05) denoting that additional oxidative stress induced by AEDs which results in seizure recurrence and drug intractability. Conclusion: Our study demonstrated that GGE patients have additional oxidative stress due to AEDs and decreased antioxidant enzyme activities causing an imbalance between oxidant and antioxidant status, which might contribute to the pathogenesis of GGE. ? 2017, Journal of Clinical and Diagnostic Research. All rights reserved.en_US
dc.identifier.citationPrasad, D. K. V., Satyanarayana, U., Shaheen, U., Surya Prabha, T., & Munshi, A. (2017). Oxidative stress in the development of genetic generalised epilepsy: An observational study in southern Indian population. Journal of Clinical and Diagnostic Research, 11(9), BC05-BC08. doi: 10.7860/JCDR/2017/29133.10604en_US
dc.identifier.doi10.7860/JCDR/2017/29133.10604
dc.identifier.issn2249782X
dc.identifier.urihttp://10.2.3.109/handle/32116/1419
dc.identifier.urlhttp://jcdr.net/article_fulltext.asp?issn=0973-709x&year=2017&volume=11&issue=9&page=BC05&issn=0973-709x&id=10604
dc.language.isoen_USen_US
dc.publisherJournal of Clinical and Diagnostic Researchen_US
dc.subjectCarbamazepineen_US
dc.subjectCatalaseen_US
dc.subjectGlutathione Peroxidaseen_US
dc.subjectMalonaldehydeen_US
dc.subjectNitric Oxideen_US
dc.subjectPhenytoinen_US
dc.subjectReactive Oxygen Metaboliteen_US
dc.subjectSuperoxide Dismutaseen_US
dc.subjectValproic Aciden_US
dc.subjectAdulten_US
dc.subjectAntioxidant Activity Case Control Studyen_US
dc.subjectControlled Studyen_US
dc.subjectDisease Courseen_US
dc.subjectFemaleen_US
dc.subjectFerric Reducing Antioxidant Power Assayen_US
dc.subjectGeneralized Epilepsyen_US
dc.subjectGenetic Disorderen_US
dc.subjectGenetic Generalized Epilepsyen_US
dc.subjectGenetic Generalized Epilepsyen_US
dc.subjectHumanen_US
dc.subjectMajor Clinical Studyen_US
dc.subjectMaleen_US
dc.subjectNerve Degenerationen_US
dc.subjectObservational Studyen_US
dc.subjectOnset Ageen_US
dc.subjectOxidative Stressen_US
dc.titleOxidative stress in the development of genetic generalised epilepsy: An observational study in southern Indian populationen_US
dc.title.journalJournal of Clinical and Diagnostic Research
dc.typeArticleen_US

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