Apert's syndrome: Study by whole exome sequencing
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Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Chongqing yi ke da xue, di 2 lin chuang xue yuan Bing du xing gan yan yan jiu suo
Abstract
In the present study we attempted a parent-child trio, whole exome sequencing (WES) approach to study Apert's syndrome. Clinical characteristics of the child were noted down and WES was carried out using Ion Torrent System that revealed the presence of previously reported P253R mutation in FGFR2 gene. Presence of two SNPs rs1047057 and rs554851880 in FGFR2 gene with an allelic frequency of 0.5113 and 0.001176 respectively and 161 complete damaging mutations were found. This study is the first reported case of exome sequencing approach on an Apert's syndrome patient aimed at providing better genetic counselling in a non-consanguineous relationship. - 2017 Chongqing Medical University
Description
Keywords
Apert syndrome, Craniosynostosis, Exome sequencing, FGFR2 gene, Parent-child trio study
Citation
Munshi, Anjana., Khetarpal, Preeti., Das, Satrupa et.al (2018) Apert's syndrome: Study by whole exome sequencing. Genes and Diseases, 72(3), 119-122. 10.1016/j.gendis.2017.07.008