Study of mitochondrial swelling, membrane fluidity and ROS production induced by nano-TiO2 and prevented by Fe incorporation

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dc.contributor.authorBarkhade T.
dc.contributor.authorMahapatra S.K.
dc.contributor.authorBanerjee I.
dc.date.accessioned2020-01-31T11:34:01Z
dc.date.accessioned2024-08-13T12:44:22Z
dc.date.available2020-01-31T11:34:01Z
dc.date.available2024-08-13T12:44:22Z
dc.date.issued2019
dc.description.abstractThe potential impact of TiO2 and Fe incorporated TiO2 nanoparticles at the organelle level has been reported. The toxicity of the samples on mitochondria isolated from chicken liver tissue has been examined through mitochondrial swelling, membrane fluidity, ROS generation capacity, and activity of complex II. The toxic effect of TiO2 was prevented by incorporating Fe into the TiO2 matrix at different concentrations. The activity of the succinate dehydrogenase enzyme complex was affected and permeabilization of the mitochondrial inner membrane to H+ and K+ and its alteration in membrane fluidity at 100 ?g mL-1 of nano-TiO2 dosage were investigated, which showed significant changes in the anisotropy of DPH-labeled mitochondria. Fe incorporation into the TiO2 matrix makes it more biocompatible by changing its structure and morphology.en_US
dc.identifier.doi10.1039/c9tx00143c
dc.identifier.issn2045452X
dc.identifier.urihttp://10.2.3.109/handle/32116/2575
dc.identifier.urlhttps://pubs.rsc.org/en/content/articlelanding/2019/tx/c9tx00143c/unauth#!divAbstract
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.titleStudy of mitochondrial swelling, membrane fluidity and ROS production induced by nano-TiO2 and prevented by Fe incorporationen_US
dc.title.journalToxicology Researchen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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