Neuroprotective effect of nerolidol in traumatic brain injury associated behavioural comorbidities in rats

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dc.contributor.authorKaur, Amandeep
dc.contributor.authorJaiswal, Gagandeep
dc.contributor.authorBrar, Jasdeep
dc.contributor.authorKumar, Puneet
dc.date.accessioned2024-01-21T10:54:57Z
dc.date.accessioned2024-08-14T07:44:18Z
dc.date.available2024-01-21T10:54:57Z
dc.date.available2024-08-14T07:44:18Z
dc.date.issued2020-11-26T00:00:00
dc.description.abstractTraumatic brain injury (TBI) is an insult to the brain from an external mechanical force, leading to temporary/permanent secondary injuries, i.e. impairment of cognitive, physical, and psycho-social functions with altered consciousness. The leading mechanism responsible for neuronal damage following TBI is an increase in oxidative reactions initiated by free radicals generated by the injury along with various other mechanisms. Nerolidol is reported to have potent antioxidant and anti-neuroinflammatory properties. The present study was designed to explore the neuroprotective effect of nerolidol in weight-drop-induced TBI in rats. Animals were injured on the 1st day by dropping a free-falling weight of 200 gm from a height of 1 m through a guide pipe onto the exposed skull. After 14 days of injury, nerolidol (25, 50, and 100 mg/kg, i.p.) treatment was given for the next 14 days. Locomotor activity and motor coordination were evaluated using an actophotometer and rotarod, respectively. Cognitive impairment was observed through the Morris Water Maze and Object Recognition Test. On the 29th day, animals were sacrificed, and their brains were collected for the biochemical estimation. The weight drop model significantly decreased locomotor activity, motor coordination, increased Acetylcholinesterase (AChE) activity, oxidative stress, and induced cognitive deficits in TBI rats. Nerolidol significantly improved locomotor activity, reversed motor incoordination and cognitive impairment, and reduced the AChE activity and oxidative/nitrosative stress. The present study demonstrates the promising neuroprotective effects of nerolidol, which might improve the quality of life of TBI patients. � 2021 The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.en_US
dc.identifier.doi10.1093/toxres/tfaa100
dc.identifier.issn2045452X
dc.identifier.urihttp://10.2.3.109/handle/32116/4284
dc.identifier.urlhttps://academic.oup.com/toxres/article/10/1/40/6046953
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.subjectbehavioural analysisen_US
dc.subjectbiochemical estimationen_US
dc.subjectnerolidolen_US
dc.subjectneuroprotective effecten_US
dc.subjectoxidative stressen_US
dc.subjecttraumatic brain injuryen_US
dc.subjectweight drop modelen_US
dc.titleNeuroprotective effect of nerolidol in traumatic brain injury associated behavioural comorbidities in ratsen_US
dc.title.journalToxicology Researchen_US
dc.typeArticleen_US
dc.type.accesstypeOpen Accessen_US

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