Vitex negundo and its medicinal value

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dc.contributor.authorGill, Balraj Singh
dc.contributor.authorMehra, Richa
dc.contributor.authorNavget
dc.contributor.authorKumar, Sanjeev
dc.date.accessioned2019-02-25T06:15:41Z
dc.date.accessioned2024-08-13T11:04:43Z
dc.date.available2019-02-25T06:15:41Z
dc.date.available2024-08-13T11:04:43Z
dc.date.issued2018
dc.description.abstractNatural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. Vitex negundo (VN), commonly known as “chaste tree”, is an ethnobotanically important plant with enormous medicinal properties. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Several bioactive compounds have been extracted from leaves, seeds, roots in form of volatile oils, flavonoids, lignans, iridoids, terpenes, and steroids. These bioactive compounds exhibit anti-inflammatory, antioxidant, antidiabetic, anticancer, antimicrobial. VN is typically known for its role in the modulation of cellular events like apoptosis, cell cycle, motility of sperms, polycystic ovary disease, and menstrual cycle. VN, reportedly, perturbs many cancer-signaling pathways involving p-p38, p-ERK1/2, and p-JNK in LPS-elicited cells, N-terminal kinase (JNK), COX-1 pathways, MAPK, NF-κB, tumor necrosis factor α (TNF-α), Akt, mTOR, vascular endothelial growth factor, hypoxia-inducible factor (HIF-1α). Several bioactive compounds obtained from VN have been commercialized and others are under investigation. This is the first review presenting up-to-date information about the VN, its bioactive constituents and their mode of action.en_US
dc.identifier.citationGill, Balraj Singh., Mehra, Richa., Navgeet et. al. (2018) Vitex negundo and its medicinal value. Molecular Biology Reports. Vol.45 (6), PP. 2925-2934. https://doi.org/10.1007/s11033-018-4421-3en_US
dc.identifier.doi10.1007/s11033-018-4421-3
dc.identifier.issnPrint- 0301-4851
dc.identifier.issnonline- 1573-4978
dc.identifier.urihttp://10.2.3.109/handle/32116/2018
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs11033-018-4421-3
dc.language.isoen_USen_US
dc.publisherSpringeren_US
dc.subjectVitex negundoen_US
dc.subjectSignalingen_US
dc.subjectReactive oxygen speciesen_US
dc.subjectCanceren_US
dc.subjectApoptosisen_US
dc.titleVitex negundo and its medicinal valueen_US
dc.title.journalMolecular Biology Reportsen_US
dc.typeArticleen_US
dc.type.accesstypeOpen Accessen_US

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