Synthesis of thiolated chlorogenic acid-capped silver nanoparticles for the effective dual action towards antimicrobial and anticancer therapy
dc.contributor.author | Nayak, Jyotsnamayee | |
dc.contributor.author | Prajapati, Kumari Sunita | |
dc.contributor.author | Kumar, Shashank | |
dc.contributor.author | Sahoo, Suban K. | |
dc.contributor.author | Kumar, Rajender | |
dc.date.accessioned | 2024-01-16T14:23:15Z | |
dc.date.accessioned | 2024-08-13T10:34:11Z | |
dc.date.available | 2024-01-16T14:23:15Z | |
dc.date.available | 2024-08-13T10:34:11Z | |
dc.date.issued | 2022-07-22T00:00:00 | |
dc.description.abstract | Chlorogenic acid (CGA) was thiolated using Traut�s reagent. Then, thiolated chlorogenic acid (CAT) functionalized on the silver nanoparticles (AgNPs). The resulting CAT-functionalized silver nanoparticles (CAT-AgNPs) have higher stability with a uniform spherical shape compared to naked AgNPs. The average particle size is 10�nm, as revealed by transmission electron microscopy (TEM). The antimicrobial activity was higher against both gram-positive and gram-negative bacteria of spherically stable nanoparticles evaluated by the disk diffusion method. Minimal inhibitory concentration (MIC) values for CAT-AgNPs were 130��g/ml for Staphylococcus aureus and 150��g/ml for Escherichia coli. Cytotoxicity studies showed that the CAT-AgNPs show maximum activity against MCF-07 cell lines with an IC50 value of 20�ng/ml. Compared to traditional noncovalent interactions, the Ag�S covalent linkage of CAT with AgNPs helped in highly stable capping. The prepared CAT-AgNPs show anticancer and antibacterial activities, thus providing an efficient antimicrobial nano-drug carrier. Nanoparticles with a dual-mode of action help in preventing fouling of nanocarriers while delivering drugs to targeted cells, opening up many applications in nanobiotechnology and nanomedicine. � 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | en_US |
dc.identifier.doi | 10.1007/s00396-022-05010-z | |
dc.identifier.issn | 0303402X | |
dc.identifier.uri | https://doi.org/10.1007/s00396-022-05010-z | |
dc.identifier.uri | https://kr.cup.edu.in/handle/32116/2884 | |
dc.language.iso | en_US | en_US |
dc.publisher | Springer Science and Business Media Deutschland GmbH | en_US |
dc.subject | Chlorogenic acid | en_US |
dc.subject | Dual therapy | en_US |
dc.subject | Silver nanoparticles | en_US |
dc.subject | Synergetic action | en_US |
dc.subject | Traut�s reagent | en_US |
dc.title | Synthesis of thiolated chlorogenic acid-capped silver nanoparticles for the effective dual action towards antimicrobial and anticancer therapy | en_US |
dc.title.journal | Colloid and Polymer Science | en_US |
dc.type | Article | en_US |
dc.type.accesstype | Closed Access | en_US |