Reconnoitering the transformative journey of minocycline from an antibiotic to an antiepileptic drug

dc.contributor.authorSingh, Tanveer
dc.contributor.authorThapliyal, Surabhi
dc.contributor.authorBhatia, Shiveena
dc.contributor.authorSingh, Varinder
dc.contributor.authorSingh, Manjinder
dc.contributor.authorSingh, Hasandeep
dc.contributor.authorKumar, Amit
dc.contributor.authorMishra, Awanish
dc.date.accessioned2024-01-21T10:38:19Z
dc.date.accessioned2024-08-13T12:05:14Z
dc.date.available2024-01-21T10:38:19Z
dc.date.available2024-08-13T12:05:14Z
dc.date.issued2022-01-20T00:00:00
dc.description.abstractMinocycline, a second-generation tetracycline antibiotic is being widely tested in animals as well as clinical settings for the management of multiple neurological disorders. The drug has shown to exert protective action in a multitude of neurological disorders including spinal-cord injury, stroke, multiple sclerosis, amyotrophic lateral sclerosis, Huntington's disease, and Parkinson's disease. Being highly lipophilic, minocycline easily penetrates the blood brain barrier and is claimed to have excellent oral absorption (~100% bioavailability). Minocycline possesses anti-inflammatory, immunomodulatory, and anti-apoptotic properties, thereby supporting its use in treating neurological disorders. The article henceforth reviews all the recent advances in the transformation of this antibiotic into a potential antiepileptic/antiepileptogenic agent. The article also gives an account of all the clinical trials undertaken till now validating the antiepileptic potential of minocycline. Based on the reported studies, minocycline seems to be an important molecule for treating epilepsy. However, the practical therapeutic implementations of this molecule require extensive mechanism-based in-vitro (cell culture) and in-vivo (animal models) studies followed by its testing in randomized, placebo controlled and double-blind clinical trials in large population as well as in different form of epilepsies. � 2022en_US
dc.identifier.doi10.1016/j.lfs.2022.120346
dc.identifier.issn243205
dc.identifier.urihttps://kr.cup.edu.in/handle/32116/3532
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0024320522000467
dc.language.isoen_USen_US
dc.publisherElsevier Inc.en_US
dc.subjectAnti-epilepticen_US
dc.subjectAntibioticsen_US
dc.subjectEpileptogenesisen_US
dc.subjectMicrogliaen_US
dc.subjectMinocyclineen_US
dc.subjectStatus epilepticusen_US
dc.titleReconnoitering the transformative journey of minocycline from an antibiotic to an antiepileptic drugen_US
dc.title.journalLife Sciencesen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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