Emerging role of ZBTB7A as an oncogenic driver and transcriptional repressor

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dc.contributor.authorGupta, S
dc.contributor.authorSingh, A.K
dc.contributor.authorPrajapati, K.S
dc.contributor.authorKushwaha, P.P
dc.contributor.authorShuaib, M
dc.contributor.authorKumar, S.
dc.date.accessioned2020-07-16T07:41:54Z
dc.date.accessioned2024-08-13T10:34:51Z
dc.date.available2020-07-16T07:41:54Z
dc.date.available2024-08-13T10:34:51Z
dc.date.issued2020
dc.description.abstractZBTB7A is a member of the POK family of transcription factors that possesses a POZ-domain at the N-terminus and Krüppel-like zinc-finger at the c-terminus. ZBTB7A was initially isolated as a protein that binds to the inducer of the short transcript of HIV-1 virus TAT gene promoter. The protein forms a homodimer through protein-protein interaction via the N-terminus POZ-domains. ZBTB7A typically binds to the DNA elements through its zinc-finger domains and represses transcription both by modification of the chromatin organization and through the direct recruitment of transcription factors to gene regulatory regions. ZBTB7A is involved in several fundamental biological processes including cell proliferation, differentiation, and development. It also participates in hematopoiesis, adipogenesis, chondrogenesis, cellular metabolism and alternative splicing of BCLXL, DNA repair, development of oligodendrocytes, osteoclast and unfolded protein response. Aberrant ZBTB7A expression promotes oncogenic transformation and tumor progression, but also maintains a tumor suppressive role depending on the type and genetic context of cancer. In this comprehensive review we provide information about the structure, function, targets, and regulators of ZBTB7A and its role as an oncogenic driver and transcriptional repressor in various human diseases. - 2020 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.canlet.2020.04.015
dc.identifier.issn3043835
dc.identifier.urihttp://10.2.3.109/handle/32116/2642
dc.identifier.urlhttps://www.sciencedirect.com/science/article/abs/pii/S0304383520302019
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectBTB domainen_US
dc.subjectCanceren_US
dc.subjectDiseaseen_US
dc.subjectZBTB7Aen_US
dc.subjectZinc fingeren_US
dc.titleEmerging role of ZBTB7A as an oncogenic driver and transcriptional repressoren_US
dc.title.journalCancer Lettersen_US
dc.typeShort Surveyen_US
dc.type.accesstypeClosed Accessen_US

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