Understanding Mutations in Human SARS-CoV-2 Spike Glycoprotein: A Systematic Review & Meta-Analysis

Simple item page
dc.contributor.authorKumar, Reetesh
dc.contributor.authorSrivastava, Yogesh
dc.contributor.authorMuthuramalingam, Pandiyan
dc.contributor.authorSingh, Sunil Kumar
dc.contributor.authorVerma, Geetika
dc.contributor.authorTiwari, Savitri
dc.contributor.authorTandel, Nikunj
dc.contributor.authorBeura, Samir Kumar
dc.contributor.authorPanigrahi, Abhishek Ramachandra
dc.contributor.authorMaji, Somnath
dc.contributor.authorSharma, Prakriti
dc.contributor.authorRai, Pankaj Kumar
dc.contributor.authorPrajapati, Dinesh Kumar
dc.contributor.authorShin, Hyunsuk
dc.contributor.authorTyagi, Rajeev K.
dc.date.accessioned2024-01-21T10:44:45Z
dc.date.accessioned2024-08-13T13:21:48Z
dc.date.available2024-01-21T10:44:45Z
dc.date.available2024-08-13T13:21:48Z
dc.date.issued2023-03-28T00:00:00
dc.description.abstractGenetic variant(s) of concern (VoC) of SARS-CoV-2 have been emerging worldwide due to mutations in the gene encoding spike glycoprotein. We performed comprehensive analyses of spike protein mutations in the significant variant clade of SARS-CoV-2, using the data available on the Nextstrain server. We selected various mutations, namely, A222V, N439K, N501Y, L452R, Y453F, E484K, K417N, T478K, L981F, L212I, N856K, T547K, G496S, and Y369C for this study. These mutations were chosen based on their global entropic score, emergence, spread, transmission, and their location in the spike receptor binding domain (RBD). The relative abundance of these mutations was mapped with global mutation D614G as a reference. Our analyses suggest the rapid emergence of newer global mutations alongside D614G, as reported during the recent waves of COVID-19 in various parts of the world. These mutations could be instrumentally imperative for the transmission, infectivity, virulence, and host immune system�s evasion of SARS-CoV-2. The probable impact of these mutations on vaccine effectiveness, antigenic diversity, antibody interactions, protein stability, RBD flexibility, and accessibility to human cell receptor ACE2 was studied in silico. Overall, the present study can help researchers to design the next generation of vaccines and biotherapeutics to combat COVID-19 infection. � 2023 by the authors.en_US
dc.identifier.doi10.3390/v15040856
dc.identifier.issn19994915
dc.identifier.urihttp://10.2.3.109/handle/32116/3852
dc.identifier.urlhttps://www.mdpi.com/1999-4915/15/4/856
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.subjectCOVID-19en_US
dc.subjectevolutionen_US
dc.subjectmutationsen_US
dc.subjectSARS-CoV-2en_US
dc.subjectspike proteinen_US
dc.subjectVoCen_US
dc.titleUnderstanding Mutations in Human SARS-CoV-2 Spike Glycoprotein: A Systematic Review & Meta-Analysisen_US
dc.title.journalVirusesen_US
dc.typeReviewen_US
dc.type.accesstypeOpen Accessen_US

Files

Collections

Zoology - Research Publications