Interleukin 1? (+3954, -511 and -31) polymorphism in chronic periodontitis patients from North India

Simple item page
dc.contributor.authorAmirisetty R.
dc.contributor.authorPatel R.P.
dc.contributor.authorDas S.
dc.contributor.authorSaraf J.
dc.contributor.authorJyothy A.
dc.contributor.authorMunshi, Anjana.
dc.date.accessioned2019-03-22T07:47:11Z
dc.date.accessioned2024-08-14T07:41:43Z
dc.date.available2019-03-22T07:47:11Z
dc.date.available2024-08-14T07:41:43Z
dc.date.issued2015
dc.description.abstractObjective. Several studies have implicated the role of interleukin-1 in various chronic diseases including periodontitis. The present study was carried out with an aim to evaluate the role of interleukin 1? polymorphisms, namely +3954C/T, -511C/T and -31T/C, in the development of chronic periodontitis. Materials and methods. Twenty-nine chronic periodontitis patients and 31 healthy controls of North Indian origin from Chhattisgarh were recruited for the study. The genotypes for the three variants were determined using the PCR-RFLP technique and the strength of association between genotypes and periodontitis was determined by odds ratio with 95% confidence interval (CI) and chi-square analysis. Results. Analysis for the +3954 allelic and genotypic frequencies of the polymorphism revealed a significant difference in the CT genotype between periodontitits patients and controls (p = 0.03). A significant difference was also observed in the allelic frequencies between the two groups (p = 0.02). For the -511 site, TT genotype revealed a significant association with the disease (p = 0.01). A significant association was also found following the co-dominant model (p = 0.007). However, the -31 polymorphism revealed no significant difference between patients and controls. Conclusions. In conclusion, the present study suggests a strong association of the TT genotype of -511 and CT genotype of +3954 variant of interleukin 1? with chronic periodontitis. However, the -31 variant did not show a significant association with the disease.en_US
dc.identifier.citationAmirisetty R., Patel R.P., Das S. et.al. (2015) Interleukin 1? (+3954, -511 and -31) polymorphism in chronic periodontitis patients from North Indiaen_US
dc.identifier.doi10.3109/00016357.2014.961958
dc.identifier.issn16357
dc.identifier.urihttp://10.2.3.109/handle/32116/2031
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.subjectChronic periodontitisen_US
dc.subjectGeneticsen_US
dc.subjectInterleukin-1?en_US
dc.subjectPolymorphismen_US
dc.titleInterleukin 1? (+3954, -511 and -31) polymorphism in chronic periodontitis patients from North Indiaen_US
dc.title.journalActa Odontologica Scandinavica
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
21.pdf
Size:
121.22 KB
Format:
Adobe Portable Document Format
Download

Collections

Human Genetics And Molecular Medicine - Research Publications