Missing link between microRNA and prostate cancer
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Springer Netherlands
Abstract
MicroRNAs are the non-coding RNAs which regulate endogenous gene expression in animal and plant cells. Alterations in the level of micro-ribonucleic acids (miRNAs) involving the deletions, overexpression, mutations, epigenetic silencing, or dysregulation of transcription factors that target specific miRNAs may culminate in various diseases including cancer. Recent findings demonstrate the role of miRNAs in prostate cancer. Numerous discoveries of miRNAs have marked the research and development surrounding prostate cancer management, diagnosis, and therapy which has made prediction easy, but the effective treatment strategy remains a mystery. This review seeks to draw a link between miRNA and prostate cancer through an understanding of the numerous signaling pathways that these miRNAs control, which may prove to be helpful in identifying therapeutically interesting molecular targets. ? 2016, International Society of Oncology and BioMarkers (ISOBM).
Description
Keywords
cetuximab, MicroRNA, MicroRNA 1, MicroRNA 101, MicroRNA 133, MicroRNA 141, MicroRNA 143, MicroRNA 145, MicroRNA 146a, MicroRNA 15a 16, MicroRNA 185, MicroRNA 188 5p, MicroRNA 200a, MicroRNA 200b, MicroRNA 200c, MicroRNA 205, MicroRNA 208, MicroRNA 218, MicroRNA 222, MicroRNA 296, MicroRNA 29b, MicroRNA 31, MicroRNA 330, MicroRNA 331 3p, MicroRNA 342, MicroRNA34a, MicroRNA 34b, MicroRNA 34c, MicroRNA 449a, Unclassified drug, Unindexed drug, Androgen, MicroRNA, RNA, Signal peptide, Tumor protein;
Citation
Gill, B. S., Alex, J. M., Navgeet, & Kumar, S. (2016). Missing link between microRNA and prostate cancer. Tumor Biology, 37(5), 5683-5704. doi: 10.1007/s13277-016-4900-x