Amino acid functionalized zinc oxide nanostructures for cytotoxicity effect and hemolytic behavior: Theoretical and experimental studies

dc.contributor.authorSingh, Satvinder
dc.contributor.authorSingh, Baljinder
dc.contributor.authorSharma, Prateek
dc.contributor.authorMittal, Anu
dc.contributor.authorKumar, Sanjeev
dc.contributor.authorSaini, G.S.S.
dc.contributor.authorTripathi, S.K.
dc.contributor.authorSingh, Gurinder
dc.contributor.authorKaura, Aman
dc.date.accessioned2018-07-14T01:18:33Z
dc.date.accessioned2024-08-13T11:04:18Z
dc.date.available2018-07-14T01:18:33Z
dc.date.available2024-08-13T11:04:18Z
dc.date.issued2017
dc.description.abstractBlending of theoretical and experimental approach, provide an important strategy in designing the nanostructure at a microscopic level and helps in predicting the response of synthesized material towards inhibition of the growth of breast cancer cell. In this work, ab initio calculations using super cell approach are performed for three different amino acids (AAs)-Histidine (His), Arginine (Arg) and Aspartic acid (Asp) coated Zinc oxide (ZnO) nanostructures to explain the growth mechanism of nanoparticles (NPs) of different shapes. Based on the first principles calculations, we reveal that ZnO-AA (Arg and Asp) NPs results in rod like and ZnO-His NPs lead to tablet like configuration. Similar morphologies are fabricated using AAs through synthetic route. The effect of concentration ratio of reactants and pH has been studied. As synthesized samples, are characterized by using Transmission Electron Microscopy (TEM), X-ray diffraction (XRD), Fourier Transform Infrared (FTIR) and UV?Vis spectroscopy techniques. Based on the results, a plausible mechanism of formation of nanostructures has been proposed. The nanostructures with rod like morphology are found to be biocompatible with normal red blood cells and show cytotoxic effect as evaluated from hemolysis and cytotoxicity assays on breast (MCF-7, T47D, MDA-MB-231) & prostate cancer (PC-3) cell lines. ? 2017 Elsevier Ltden_US
dc.identifier.citationSingh, S., Singh, B., Sharma, P., Mittal, A., Kumar, S., Saini, G. S. S., . . . Kaura, A. (2017). Amino acid functionalized zinc oxide nanostructures for cytotoxicity effect and hemolytic behavior: Theoretical and experimental studies. Materials and Design, 134, 10-22. doi: 10.1016/j.matdes.2017.08.020en_US
dc.identifier.doi10.1016/j.matdes.2017.08.020
dc.identifier.issn2641275
dc.identifier.urihttps://kr.cup.edu.in/handle/32116/1228
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0264127517307669?via%3Dihub
dc.language.isoen_USen_US
dc.publisherElsevier Ltden_US
dc.subjectAmino acidsen_US
dc.subjectBinding energyen_US
dc.subjectBiocompatibilityen_US
dc.subjectBlendingen_US
dc.subjectBlooden_US
dc.subjectCalculationsen_US
dc.subjectCell cultureen_US
dc.subjectCellsen_US
dc.subjectCytologyen_US
dc.subjectCytotoxicityen_US
dc.subjectDiseasesen_US
dc.subjectFourier transform infrared spectroscopyen_US
dc.subjectHigh resolution transmission electron microscopyen_US
dc.subjectNanoparticlesen_US
dc.subjectTransmission electron microscopyen_US
dc.subjectX ray diffractionen_US
dc.subjectZincen_US
dc.subjectZinc oxideen_US
dc.subjectAb initio calculationsen_US
dc.subjectExperimental approachesen_US
dc.subjectFirst-principles calculationen_US
dc.subjectFourier transform infrareden_US
dc.subjectHemolysisen_US
dc.subjectPartial density of stateen_US
dc.subjectZinc oxide nanoparticlesen_US
dc.subjectZinc oxide nanostrucen_US
dc.titleAmino acid functionalized zinc oxide nanostructures for cytotoxicity effect and hemolytic behavior: Theoretical and experimental studiesen_US
dc.title.journalMaterials and Design
dc.typeArticleen_US

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