miR-590�5p: A double-edged sword in the oncogenesis process

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dc.contributor.authorBarwal, Tushar Singh
dc.contributor.authorSingh, Neha
dc.contributor.authorSharma, Uttam
dc.contributor.authorBazala, Sonali
dc.contributor.authorRani, Medha
dc.contributor.authorBehera, Alisha
dc.contributor.authorKumawat, Ram Kumar
dc.contributor.authorKumar, Pawan
dc.contributor.authorUttam, Vivek
dc.contributor.authorKhandelwal, Akanksha
dc.contributor.authorBarwal, Jyoti
dc.contributor.authorJain, Manju
dc.contributor.authorJain, Aklank
dc.date.accessioned2024-01-16T14:23:14Z
dc.date.accessioned2024-08-13T10:34:11Z
dc.date.available2024-01-16T14:23:14Z
dc.date.available2024-08-13T10:34:11Z
dc.date.issued2022-06-12T00:00:00
dc.description.abstractAccumulating evidence suggests the critical role of miR-590�5p in various aspects of cellular homeostasis, including cancer. Furthermore, we and others have recently demonstrated that miRNA-590�5p acts as an oncogene in some cancers while it acts as a tumor-suppressor in others. However, the role of miR-590�5p in oncogenesis is more complex, like a double-edged sword. Thus, this systematic review introduces the concept, mechanism, and biological function of miR-590�5p to resolve this apparent paradox. We have also described the involvement of miR-590�5p in crucial cancer-hallmarks processes like proliferation, invasion, metastasis, and chemo radioresistance. Finally, we have presented the possible genes/pathways targets of miR-590�5p through bioinformatics analysis. This review may help in designing better biomarkers and therapeutic targets for cancers. � 2022en_US
dc.identifier.doi10.1016/j.ctarc.2022.100593
dc.identifier.issn24682942
dc.identifier.urihttps://doi.org/10.1016/j.ctarc.2022.100593
dc.identifier.urihttp://10.2.3.109/handle/32116/2882
dc.language.isoen_USen_US
dc.publisherElsevier Ltden_US
dc.subjectBiomarkeren_US
dc.subjectCanceren_US
dc.subjectMicroRNAen_US
dc.subjectmiR-590-5pen_US
dc.subjectTherapeutic targeten_US
dc.titlemiR-590�5p: A double-edged sword in the oncogenesis processen_US
dc.title.journalCancer Treatment and Research Communicationsen_US
dc.typeReviewen_US
dc.type.accesstypeOpen Accessen_US

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Biochemistry And Microbial Sciences - Research Publications