Chemical composition, in�vitro and in silico evaluation of essential oil from Eucalyptus tereticornis leaves for lung cancer
| dc.contributor.author | Anju | |
| dc.contributor.author | Kumar, Amit | |
| dc.contributor.author | Yadav, Poonam | |
| dc.contributor.author | Navik, Umashanker | |
| dc.contributor.author | Jaitak, Vikas | |
| dc.date.accessioned | 2024-01-21T10:55:05Z | |
| dc.date.accessioned | 2024-08-14T07:44:21Z | |
| dc.date.available | 2024-01-21T10:55:05Z | |
| dc.date.available | 2024-08-14T07:44:21Z | |
| dc.date.issued | 2022-08-08T00:00:00 | |
| dc.description.abstract | Chemical composition of the essential oil (EO) of Eucalyptus tereticornis leaves was studied by gas chromatography�mass spectrometry. Forty-five constituents were identified in the oil hydrodistilled from the sample collected from Ghudda Village, Bathinda (Pb), India of which eucalyptol (34.39%) and ledol (9.92%) were the major constituents. In vitro antioxidant and anticancer potential of EO was analysed by DPPH 2,2-diphenylpicrylhydrazyl (DPPH) and MTT assay. The percentage free radical scavenging activity was found to be 63.77%. The antiproliferative activity was analysed using MTT assay in adenocarcinomic human alveolar basal epithelial A549 cancer cell line and showed IC50 value of 47.14 �g/ml. In silico study of EO, constituents were performed using Maestro 12.9 against EGFR (PDB ID-2RGP). Five constituents from EO showed high dockscore as compared to standard Mobicertinib which indicated the effectiveness of oil constituents against lung cancer. � 2022 Informa UK Limited, trading as Taylor & Francis Group. | en_US |
| dc.identifier.doi | 10.1080/14786419.2022.2107642 | |
| dc.identifier.issn | 14786419 | |
| dc.identifier.uri | http://10.2.3.109/handle/32116/4331 | |
| dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/14786419.2022.2107642 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Taylor and Francis Ltd. | en_US |
| dc.subject | antioxidant | en_US |
| dc.subject | antiproliferation | en_US |
| dc.subject | essential oil | en_US |
| dc.subject | Eucalyptus tereticornis | en_US |
| dc.subject | GC�MS | en_US |
| dc.subject | in silico | en_US |
| dc.subject | lung cancer | en_US |
| dc.title | Chemical composition, in�vitro and in silico evaluation of essential oil from Eucalyptus tereticornis leaves for lung cancer | en_US |
| dc.title.journal | Natural Product Research | en_US |
| dc.type | Article | en_US |
| dc.type.accesstype | Open Access | en_US |