Iodine-Catalysed Synthesis of ?-Carboline Tethered ?-Amino Amidines Through Ugi-Type Multicomponent Reaction

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dc.contributor.authorSingh, Manpreet
dc.contributor.authorVaishali
dc.contributor.authorJamra, Rahul
dc.contributor.authorDeepika
dc.contributor.authorKumar, Sunit
dc.contributor.authorSingh, Virender
dc.date.accessioned2024-01-21T10:33:03Z
dc.date.accessioned2024-08-13T11:16:17Z
dc.date.available2024-01-21T10:33:03Z
dc.date.available2024-08-13T11:16:17Z
dc.date.issued2022-09-15T00:00:00
dc.description.abstractA simple and efficient iodine catalysed protocol has been unfolded for the synthesis of novel ?-carboline C1-linked ?-amino amidines via one-pot assembly of 1-formyl ?-carbolines (Kumujian C analogues), anilines and isocyanides. This domino strategy proceeds through the formation of three C?N bonds in a single operation. The advantageous features of the developed methodology include one-pot synthesis, operational simplicity, high atom economy, broad substrate scope, multicomponent character, easy purification procedure (no column chromatography) and applicability towards gram scale synthesis. The scope of strategy has been demonstrated with the construction of a library of 32 novel ?-carboline tethered ?-amino amidines having three points of diversity. � 2022 Wiley-VCH GmbH.en_US
dc.identifier.doi10.1002/slct.202202392
dc.identifier.issn23656549
dc.identifier.urihttps://kr.cup.edu.in/handle/32116/3253
dc.identifier.urlhttps://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202202392
dc.language.isoen_USen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.subjectIodine catalyseden_US
dc.subjectKumujian Cen_US
dc.subjectUgi-type reactionen_US
dc.subject?-Amino amidinesen_US
dc.subject?-carbolineen_US
dc.titleIodine-Catalysed Synthesis of ?-Carboline Tethered ?-Amino Amidines Through Ugi-Type Multicomponent Reactionen_US
dc.title.journalChemistrySelecten_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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