Role of platelet in Parkinson's disease: Insights into pathophysiology & theranostic solutions

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dc.contributor.authorBeura, Samir Kumar
dc.contributor.authorPanigrahi, Abhishek Ramachandra
dc.contributor.authorYadav, Pooja
dc.contributor.authorSingh, Sunil Kumar
dc.date.accessioned2024-01-21T10:44:40Z
dc.date.accessioned2024-08-13T13:21:44Z
dc.date.available2024-01-21T10:44:40Z
dc.date.available2024-08-13T13:21:44Z
dc.date.issued2022-07-04T00:00:00
dc.description.abstractParkinson's disease (PD) is the second-most-common neurodegenerative disease characterized by motor and non-motor dysfunctions, which currently affects about 10 million people worldwide. Gradual death and progressive loss of dopaminergic neurons in the pars compacta region of substantia nigra result in striatal dopamine deficiency in PD. Specific mutation with further aggregation of ??synuclein in the intraneuronal inclusion bodies is considered the neuropathological hallmark of this disease. PD is often associated with various organelle dysfunctions inside a dopaminergic neuron, including mitochondrial damage, proteasomal impairment, and production of reactive oxygen species, thus causing subsequent neuronal death. Apart from several genetic and non-genetic risk factors, emerging research establishes an association between cardiovascular diseases, including coronary heart disease, myocardial infarction, congestive heart failure, and ischemic stroke with PD. The majority of these cardiovascular diseases have an origin from atherosclerosis, where endothelial dysfunction following thrombus formation is significantly regulated by blood platelet. This non-nucleated cell fragment expresses not only neuron-specific molecules and receptors but also several PD-specific biomarkers such as ?-synuclein, parkin, PTEN-induced kinase-1, tyrosine hydroxylase, dopamine transporter, thus making platelet a suitable peripheral model for PD. Besides its similarity with a dopaminergic neuron, platelet structural alterations, as well as functional abnormalities, are also evident in PD. However, the molecular mechanism behind platelet dysfunction is still elusive and quite controversial. This state-of-the-art review describes the detailed mechanism of platelet impairment in PD, addressing the novel platelet-associated therapeutic drug candidates for plausible PD management. � 2022 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.arr.2022.101681
dc.identifier.issn15681637
dc.identifier.urihttp://10.2.3.109/handle/32116/3825
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S1568163722001234
dc.language.isoen_USen_US
dc.publisherElsevier Ireland Ltden_US
dc.subjectBlood plateleten_US
dc.subjectDopamineen_US
dc.subjectMitochondriaen_US
dc.subjectParkinson's diseaseen_US
dc.subjectSubstantia nigraen_US
dc.subject??synucleinen_US
dc.titleRole of platelet in Parkinson's disease: Insights into pathophysiology & theranostic solutionsen_US
dc.title.journalAgeing Research Reviewsen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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