Modulating autophagy and mitophagy as a promising therapeutic approach in neurodegenerative disorders

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dc.contributor.authorMishra, Jayapriya
dc.contributor.authorBhatti, Gurjit Kaur
dc.contributor.authorSehrawat, Abhishek
dc.contributor.authorSingh, Charan
dc.contributor.authorSingh, Arti
dc.contributor.authorReddy, Arubala P.
dc.contributor.authorReddy, P. Hemachandra
dc.contributor.authorBhatti, Jasvinder Singh
dc.date.accessioned2024-01-21T10:54:09Z
dc.date.accessioned2024-08-14T07:40:54Z
dc.date.available2024-01-21T10:54:09Z
dc.date.available2024-08-14T07:40:54Z
dc.date.issued2022-11-04T00:00:00
dc.description.abstractThe high prevalence of neurodegenerative diseases has become a major public health challenge and is associated with a tremendous burden on individuals, society and federal governments worldwide. Protein misfolding and aggregation are the major pathological hallmarks of several neurodegenerative disorders. The cells have evolved several regulatory mechanisms to deal with aberrant protein folding, namely the classical ubiquitin pathway, where ubiquitination of protein aggregates marks their degradation via lysosome and the novel autophagy or mitophagy pathways. Autophagy is a catabolic process in eukaryotic cells that allows the lysosome to recycle the cell's own contents, such as organelles and proteins, known as autophagic cargo. Their most significant role is to keep cells alive in distressed situations. Mitophagy is also crucial for reducing abnormal protein aggregation and increasing organelle clearance and partly accounts for maintaining cellular homeostasis. Furthermore, substantial data indicate that any disruption in these homeostatic mechanisms leads to the emergence of several age-associated metabolic and neurodegenerative diseases. So, targeting autophagy and mitophagy might be a potential therapeutic strategy for a variety of health conditions. � 2022en_US
dc.identifier.doi10.1016/j.lfs.2022.121153
dc.identifier.issn243205
dc.identifier.urihttp://10.2.3.109/handle/32116/4231
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0024320522008530
dc.language.isoen_USen_US
dc.publisherElsevier Inc.en_US
dc.subjectAggregationen_US
dc.subjectAutophagic cargoen_US
dc.subjectAutophagyen_US
dc.subjectFunctional foodsen_US
dc.subjectHomeostasisen_US
dc.subjectMisfoldingen_US
dc.subjectMitophagyen_US
dc.subjectNeurodegenerative disordersen_US
dc.titleModulating autophagy and mitophagy as a promising therapeutic approach in neurodegenerative disordersen_US
dc.title.journalLife Sciencesen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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