Spotlight on liver macrophages for halting liver disease progression and injury

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dc.contributor.authorKhurana, Amit
dc.contributor.authorNavik, Umashanker
dc.contributor.authorAllawadhi, Prince
dc.contributor.authorYadav, Poonam
dc.contributor.authorWeiskirchen, Ralf
dc.date.accessioned2024-01-21T10:55:07Z
dc.date.accessioned2024-08-14T07:44:22Z
dc.date.available2024-01-21T10:55:07Z
dc.date.available2024-08-14T07:44:22Z
dc.date.issued2022-10-07T00:00:00
dc.description.abstractIntroduction: Over the past two decades, understanding of hepatic macrophage biology has provided astounding details of their role in the progression and regression of liver diseases. The hepatic macrophages constitute resident macrophages, Kupffer cells, and circulating bone marrow monocyte-derived macrophages, which play a diverse role in liver injury and repair. Imbalance in the macrophage population leads to pathological consequences and is responsible for the initiation and progression of acute and chronic liver injuries. Further, distinct populations of hepatic macrophages and their high heterogeneity make their complex role enigmatic. The unique features of distinct phenotypes of macrophages have provided novel biomarkers for defining the stages of liver diseases. The distinct mechanisms of hepatic macrophages polarization and recruitment have been at the fore front of research. In addition, the secretome of hepatic macrophages and their immune regulation has provided clinically relevant therapeutic targets. Areas covered: Herein, we have highlighted the current understanding in the area of hepatic macrophages, and their role in the progression of liver injury. Expert opinion: It is essential to ascertain the physiological and pathological role of evolutionarily conserved distinct macrophage phenotypes in different liver diseases before viable approaches may see a clinical translation. � 2022 Informa UK Limited, trading as Taylor & Francis Group.en_US
dc.identifier.doi10.1080/14728222.2022.2133699
dc.identifier.issn14728222
dc.identifier.urihttp://10.2.3.109/handle/32116/4341
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.1080/14728222.2022.2133699
dc.language.isoen_USen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.subjectLiver diseasesen_US
dc.subjectmacrophage polarizationen_US
dc.subjectmacrophage targetingen_US
dc.subjectmacrophagesen_US
dc.subjectphenotypeen_US
dc.titleSpotlight on liver macrophages for halting liver disease progression and injuryen_US
dc.title.journalExpert Opinion on Therapeutic Targetsen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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