A short review on cross-link between pyruvate kinase (PKM2) and Glioblastoma Multiforme

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dc.contributor.authorVerma, Harkomal
dc.contributor.authorCholia, Ravi P.
dc.contributor.authorKaur, Sharanjot
dc.contributor.authorDhiman, Monisha
dc.contributor.authorMantha, Anil K.
dc.date.accessioned2024-01-21T10:37:02Z
dc.date.accessioned2024-08-13T11:19:29Z
dc.date.available2024-01-21T10:37:02Z
dc.date.available2024-08-13T11:19:29Z
dc.date.issued2021-03-02T00:00:00
dc.description.abstractPyruvate kinase (PK) catalyzes the last irreversible reaction of glycolysis pathway, generating pyruvate and ATP, from Phosphoenol Pyruvate (PEP) and ADP precursors. In mammals, four different tissue-specific isoforms (M1, M2, L and R) of PK exist, which are translated from two genes (PKL and PKR). PKM2 is the highly expressed isoform of PK in cancers, which regulates the aerobic glycolysis via reprogramming cancer cell�s metabolic pathways�to provide an anabolic�advantage to the tumor cells. In addition to the established role of PKM2 in aerobic glycolysis of multiple cancer types, various recent findings have highlighted the non-metabolic functions of PKM2 in brain tumor development. Nuclear PKM2 acts as a co-activator and directly regulates gene transcription. PKM2 dependent transactivation of various oncogenic genes is instrumental in the progression and aggressiveness of Glioblastoma Multiforme (GBM). Also, PKM2 acts as a protein kinase in histone modification which regulates gene expression and tumorigenesis. Ongoing research has explored novel regulatory mechanisms of PKM2 and its association in GBM progression. This review enlists and summarizes the metabolic and non-metabolic roles of PKM2 at the cellular level, and its regulatory function highlights the importance of the nuclear functions of PKM2 in GBM progression, and an emerging role of PKM2 as novel cancer therapeutics. � 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.en_US
dc.identifier.doi10.1007/s11011-021-00690-y
dc.identifier.issn8857490
dc.identifier.urihttp://10.2.3.109/handle/32116/3463
dc.identifier.urlhttps://link.springer.com/10.1007/s11011-021-00690-y
dc.language.isoen_USen_US
dc.publisherSpringeren_US
dc.subjectCanceren_US
dc.subjectGlioblastomaen_US
dc.subjectGlycolysisen_US
dc.subjectPKM1en_US
dc.subjectPKM2en_US
dc.subjectPyruvate kinaseen_US
dc.titleA short review on cross-link between pyruvate kinase (PKM2) and Glioblastoma Multiformeen_US
dc.title.journalMetabolic Brain Diseaseen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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