Oxidative stress and inflammation in cardiovascular diseases: Two sides of the same coin

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dc.contributor.authorDhiman, Monisha
dc.contributor.authorThakur, Shweta
dc.contributor.authorUpadhyay, Shishir
dc.contributor.authorKaur, Amandeep
dc.contributor.authorMantha, Anil K.
dc.date.accessioned2013-01-11T14:18:29Z
dc.date.accessioned2024-08-13T13:22:20Z
dc.date.available2013-01-11T14:18:29Z
dc.date.available2024-08-13T13:22:20Z
dc.date.issued2015
dc.description.abstractGlobally, the major cause of long- term disability and death is an ?epidemiologic transition? from infectious diseases and malnutrition complications to non-communicable chronic diseases like cardiovascular disease (CVD), cancer and diabetes. CVD accounts for major global mortality. Imbalance due to the generation of reactive oxygen species (ROS) levels above normal baseline levels and decreased antioxidant defence reserve makes the cardiovascular system (cardiac and vascular cells) susceptible to oxidative stress and damage. Growing evidences support the notion that oxidative stress plays a crucial role in the development and progression of CVD by altering normal functions such as inactivation of nitric oxide (NO) leading to endothelial dysfunction, intracellular Ca2+overload and others. Oxidative stress also mediates inflammation through various signalling cascades such as the activation of inflammatory transcription factors (TFs) namely NF-?B, AP-1 and Nrf-1. A vicious cycle of oxidative stress-mediated inflammation and inflammation- induced oxidative stress makes the CVD-related complications worse. Therefore, it is also very important to clearly understand the role of enzymatic sources of RO mechanisms underlying pathological conditions and link between oxidative stress and inflammation during each stage of CVD. The present chapter will elucidate the role of oxidative stress and inflammation in CVD development and progression. It is important to find the remedial measures, to develop the efficient biomarkers and to design the therapeutic strategies for CVD in the near future. ? Springer India 2015.en_US
dc.identifier.citationDhiman, M., Thakur, S., Upadhyay, S., Kaur, A., & Mantha, A. K. (2015). Oxidative stress and inflammation in cardiovascular diseases: Two sides of the same coin Free Radicals in Human Health and Disease (pp. 259-278).en_US
dc.identifier.doi10.1007/978-81-322-2035-0_17
dc.identifier.isbn9788132220350
dc.identifier.isbn9788132220343
dc.identifier.urihttp://10.2.3.109/handle/32116/370
dc.identifier.urlhttps://link.springer.com/chapter/10.1007%2F978-81-322-2035-0_17
dc.language.isoen_USen_US
dc.publisherSpringer Indiaen_US
dc.titleOxidative stress and inflammation in cardiovascular diseases: Two sides of the same coinen_US
dc.title.journalFree Radicals in Human Health and Disease
dc.typeBook Chapteren_US

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