Efficacy of p-coumaric acid in chronic constriction injury induced neuropathic pain in rats

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dc.contributor.authorBharti, Akash
dc.contributor.authorKaur, Jaspreet
dc.contributor.authorKumar, Amit
dc.contributor.authorSingh, Simranjit
dc.contributor.authorKumar, Deepak
dc.date.accessioned2024-01-21T10:38:19Z
dc.date.accessioned2024-08-13T12:05:14Z
dc.date.available2024-01-21T10:38:19Z
dc.date.available2024-08-13T12:05:14Z
dc.date.issued2021-12-14T00:00:00
dc.description.abstractThe present research work has been designed to evaluate the effect of p-coumaric acid in chronic constriction injury (CCI) of sciatic nerve induced neuropathic pain in rats. In addition, biochemical tests such as thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and total protein were performed in sciatic nerve tissue sample. The neuropathic pain has been effi ciently and successfully induced in rat by the performance of CCI. The battery of behavioural test showed the development of neuropathic pain as an index of rising the paw and tail thermal and mechanical pain sensitivity. The treatment of p-coumaric acid at dose 50 and 100 mg kg-1, p.o. for 15 consecutive days have been shown to produce signifi cant ameliorative effect on CCI of sciatic nerve induced neuropathic pain sensitivity. In addition, CCI of sciatic nerve also induces the oxidative stress in nervous system by rising TBARS, decrease GSH and proteins levels in sciatic nerve tissue and these effects are reversed via administration of p-coumaric acid and statistically equivalent to standard drug. Hence, it may be concluded that, p-coumaric acid can be useful in the management of neuropathic pain symptoms. � 2021 Indian Drug Manufacturers' Association. All rights reserved.en_US
dc.identifier.doi10.53879/id.58.09.12733
dc.identifier.issn0019462X
dc.identifier.urihttp://10.2.3.109/handle/32116/3530
dc.identifier.urlhttp://www.indiandrugsonline.org/issuesarticle-details?id=MTIyNQ==
dc.language.isoen_USen_US
dc.publisherIndian Drug Manufacturers' Associationen_US
dc.subjectChronic constriction injuryen_US
dc.subjectFlavonoidsen_US
dc.subjectNeuropathic painen_US
dc.subjectP-coumaric aciden_US
dc.titleEfficacy of p-coumaric acid in chronic constriction injury induced neuropathic pain in ratsen_US
dc.title.journalIndian Drugsen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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